Title:
DRUG TARGETING CANCER STEM CELL
Document Type and Number:
WIPO Patent Application WO/2018/117196
Kind Code:
A1
Abstract:
Provided is an antitumor agent which comprises a compound represented by formula (1) or a pharmaceutically acceptable salt thereof combined with at least one medicinal agent selected from the group consisting of an anticancer agent, a remedy for diabetes, a remedy for hyperlipidemia, a remedy for multiple sclerosis, a steroidal antiinflammatory drug, a non-steroidal antiinflammatory drug, an antifungal drug and pharmaceutically acceptable salts thereof. [In formula (1): ring Q1 represents optionally substituted C6-10 aryl, etc.; R1 and R2 independently represent a hydrogen atom, etc.; W1 represents C1-4 alkylene optionally substituted by 1-3 fluorine atoms or C3-7 cycloalkyl; W2 represents -NR4aC(O)-, etc. (wherein R4a represents a hydrogen atom or C1-6 alkyl); and ring Q2 represents optionally substituted C6-10 aryl, etc.]
Inventors:
FUKUNAGA YUICHI (JP)
YAMAKAWA ERINA (JP)
SUGARU EIJI (JP)
IKEDA SATOSHI (JP)
OTSUBO TSUGUTERU (JP)
UMEHARA HIROKI (JP)
LI CHIANG JIA (US)
YAMAKAWA ERINA (JP)
SUGARU EIJI (JP)
IKEDA SATOSHI (JP)
OTSUBO TSUGUTERU (JP)
UMEHARA HIROKI (JP)
LI CHIANG JIA (US)
Application Number:
PCT/JP2017/045836
Publication Date:
June 28, 2018
Filing Date:
December 20, 2017
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K31/4164; A61K31/4178; A61K31/422; A61K31/427; A61K31/437; A61K31/4375; A61K31/4439; A61K31/4709; A61K31/4725; A61K31/497; A61K31/5365; A61K45/00; A61P35/00
Domestic Patent References:
| WO2015178426A1 | 2015-11-26 | |||
| WO2016027253A1 | 2016-02-25 | |||
| WO2017146128A1 | 2017-08-31 | |||
| WO2016208591A1 | 2016-12-29 | |||
| WO2016208592A1 | 2016-12-29 | |||
| WO2014125444A1 | 2014-08-21 | |||
| WO2009056556A1 | 2009-05-07 | |||
| WO2006065215A1 | 2006-06-22 |
Other References:
BOMAN ET AL., JOURNAL OF CLINICAL ONCOLOGY, vol. 26, no. 17, 2008, pages 2795 - 2799
LOBO ET AL., ANNU REV CELL DEV BIOL, vol. 23, 2007, pages 675 - 99
AL-HAJJ ET AL., ONCOGENE, vol. 23, no. 43, 2004, pages 7274 - 82
PONTI ET AL., CANCER RES, vol. 65, no. 13, 2005, pages 5506 - 5511
CARMERO ET AL., CANCER TREATMENT REVIEWS, vol. 49, 2016, pages 25 - 36
ZHANG ET AL., STEM CELLS TRANSLATIONAL MEDICINE, vol. 2, 2013, pages 233 - 242
THE 27TH MEDICINAL CHEMISTRY SYMPOSIUM ABSTRACT, pages 166 - 167
MONTHLY FINE CHEMICALS, vol. 38, no. 8, August 2009 (2009-08-01), pages 12 - 24
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS, INC.
R. C. LAROCK ET AL.: "Comprehensive Organic Transformation", 1989, VCH PUBLISHER INC.
PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 10330 - 10334
See also references of EP 3560494A4
LOBO ET AL., ANNU REV CELL DEV BIOL, vol. 23, 2007, pages 675 - 99
AL-HAJJ ET AL., ONCOGENE, vol. 23, no. 43, 2004, pages 7274 - 82
PONTI ET AL., CANCER RES, vol. 65, no. 13, 2005, pages 5506 - 5511
CARMERO ET AL., CANCER TREATMENT REVIEWS, vol. 49, 2016, pages 25 - 36
ZHANG ET AL., STEM CELLS TRANSLATIONAL MEDICINE, vol. 2, 2013, pages 233 - 242
THE 27TH MEDICINAL CHEMISTRY SYMPOSIUM ABSTRACT, pages 166 - 167
MONTHLY FINE CHEMICALS, vol. 38, no. 8, August 2009 (2009-08-01), pages 12 - 24
T. W. GREENEP. G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY AND SONS, INC.
R. C. LAROCK ET AL.: "Comprehensive Organic Transformation", 1989, VCH PUBLISHER INC.
PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 10330 - 10334
See also references of EP 3560494A4
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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