Title:
DRUG FOR TREATING SYMPTOM OF CEREBRAL INFARCTION IN ACUTE STAGE CEREBRAL INFARCTION PATIENT
Document Type and Number:
WIPO Patent Application WO/2021/112207
Kind Code:
A1
Abstract:
The present invention provides a means for treating a symptom of cerebral infarction in a cerebral infarction patient, particularly in an acute stage cerebral infarction patient, without causing undesirable side effects, by optimizing the administration and dosage of a drug that includes, as an active ingredient, adrenomedullin (AM) or a derivative thereof having adrenomedullin activity. One aspect of the present invention relates to a drug for treating a symptom of cerebral infarction in an acute stage cerebral infarction patient, said drug including, as an active ingredient, adrenomedullin or a derivative thereof having adrenomedullin activity, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of any of these.
Inventors:
IHARA MASAFUMI (JP)
SAITO SATOSHI (JP)
YOSHIMOTO TAKESHI (JP)
KITAMURA KAZUO (JP)
KITA TOSHIHIRO (JP)
SAITO SATOSHI (JP)
YOSHIMOTO TAKESHI (JP)
KITAMURA KAZUO (JP)
KITA TOSHIHIRO (JP)
Application Number:
PCT/JP2020/045158
Publication Date:
June 10, 2021
Filing Date:
December 04, 2020
Export Citation:
Assignee:
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
UNIV MIYAZAKI (JP)
UNIV MIYAZAKI (JP)
International Classes:
A61K38/16; A61P7/02; A61P9/00; A61P9/10; C07K14/47; C07K14/575; C12N15/16
Domestic Patent References:
| WO2012096411A1 | 2012-07-19 |
Other References:
CHAUNG WAYNE W., WU RONGQIAN, JI YOUXIN, WANG ZHIMIN, DONG WEIFENG, CHEYUO CLETUS, QI LEI, QIANG XIAOLING, WANG HAICHAO, WANG PING: "Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats", MOLECULAR MEDICINE, vol. 17, no. 9-10, September 2011 (2011-09-01), pages 1075 - 1083, XP055832082
MIYAMOTO, NOBUKAZU ET AL.: "Adrenomedullin", IMPORTANCE OF ADRENOMEDULLIN IN ACUTE CEREBRAL ISCHEMIA, STROKE, METHOD, CONCLUSION, vol. 30, no. 2, 2008, pages 304
KITA, TOSHIHIRO ET AL.: "Various effects of adrenomedullin revealed by long-term administration to patients with a history of cerebral infarction", THE 28TH GENERAL MEETING OF JAPANESE SOCIETY OF HYPERTENSION PROGRAM/ABSTRACTS, METHOD, CONCLUSION, 2005, pages 66
ZHANG HAO; TANG BO; YIN CONG-GUO; CHEN YAN; MENG QING-LIAN; JIANG LIN; WANG WEI-PING; NIU GUO-ZHONG: "Plasma adrenomedullin levels are associated with long-term outcomes of acute ischemic stroke", PEPTIDES, vol. 52, 2013, pages 44 - 48, XP028624029, DOI: 10.1016/j.peptides.2013.11.025
MIYAMOTO, NOBUKAZU ET AL.: "Adrenomedullin", IMPORTANCE OF ADRENOMEDULLIN IN ACUTE CEREBRAL ISCHEMIA, STROKE, METHOD, CONCLUSION, vol. 30, no. 2, 2008, pages 304
KITA, TOSHIHIRO ET AL.: "Various effects of adrenomedullin revealed by long-term administration to patients with a history of cerebral infarction", THE 28TH GENERAL MEETING OF JAPANESE SOCIETY OF HYPERTENSION PROGRAM/ABSTRACTS, METHOD, CONCLUSION, 2005, pages 66
ZHANG HAO; TANG BO; YIN CONG-GUO; CHEN YAN; MENG QING-LIAN; JIANG LIN; WANG WEI-PING; NIU GUO-ZHONG: "Plasma adrenomedullin levels are associated with long-term outcomes of acute ischemic stroke", PEPTIDES, vol. 52, 2013, pages 44 - 48, XP028624029, DOI: 10.1016/j.peptides.2013.11.025
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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