Title:
DRUG FOR TREATMENT OR PREVENTION OF CEREBRAL HEMORRHAGE, AND METHOD FOR TREATMENT OR PREVENTION OF CEREBRAL HEMORRHAGE USING SAID DRUG
Document Type and Number:
WIPO Patent Application WO/2021/100031
Kind Code:
A1
Abstract:
Provided is a drug used for the treatment or prevention of cerebral hemorrhage, the drug containing, as active ingredients: the compound of formula (I) or a medically acceptable salt thereof; and an ester or a solvate. 74
Inventors:
TOMINAGA TEIJI (JP)
NIIZUMA KUNIYASU (JP)
NIIZUMA KUNIYASU (JP)
Application Number:
PCT/IB2020/061485
Publication Date:
May 27, 2021
Filing Date:
December 04, 2020
Export Citation:
Assignee:
TMS CO LTD (JP)
International Classes:
A61K31/407; A61K31/501; A61P7/04; C07D491/052; C07D519/00
Domestic Patent References:
| WO2011004620A1 | 2011-01-13 | |||
| WO2004002488A1 | 2004-01-08 |
Other References:
SHIBATA, K. ET AL.: "Evaluation of the effects of a new series of SMTPs in the acetic acid-induced embolic cerebral infarct mouse model", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 818, 2018, pages 221 - 227, XP085313014, DOI: 10.1016/j.ejphar.2017.10.055
MATSUMOTO, N. ET AL.: "Soluble Epoxide Hydrolase as an Anti-inflammatory Target of the Thrombolytic Stroke Drug SMTP-7", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 52, 2014, pages 35826 - 35838, XP055640349, DOI: 10.1074/jbc.M114.588087
ITO, A. ET AL.: "SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice", BRAIN RESEARCH, vol. 1578, 2014, pages 38 - 48, XP029044222, DOI: 10.1016/j.brainres.2014.07.004
MATSUMOTO, N. ET AL.: "Soluble Epoxide Hydrolase as an Anti-inflammatory Target of the Thrombolytic Stroke Drug SMTP-7", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 52, 2014, pages 35826 - 35838, XP055640349, DOI: 10.1074/jbc.M114.588087
ITO, A. ET AL.: "SMTP-7, a new thrombolytic agent, decreases hemorrhagic transformation after transient middle cerebral artery occlusion under warfarin anticoagulation in mice", BRAIN RESEARCH, vol. 1578, 2014, pages 38 - 48, XP029044222, DOI: 10.1016/j.brainres.2014.07.004
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
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