Title:
DRUGS COMPRISING PROTEIN FORMING HOLLOW NANOPARTICLES AND THERAPEUTIC SUBSTANCE TO BE TRANSFERRED INTO CELLS FUSED THEREWITH
Document Type and Number:
WIPO Patent Application WO/2003/082345
Kind Code:
A1
Abstract:
It is intended to provide drugs for treating diseases specifically acting on target cells or tissues with the use of hollow protein nanoparticles, wherein a protein drug can be efficiently encapsulated in the particles, and a treatment method with the use of these drugs. These drugs comprise hollow protein nanoparticles made of a protein, which is capable of recognizing specific cells such as liver cells and forming particles (for example, hepatitis B virus surface antigen protein), and a therapeutic substance to be transferred into cells (for example, an interferon, a liver cell growth factor, etc.) fused with the protein.
Inventors:
KURODA SHUNICHI (JP)
TANIZAWA KATSUYUKI (JP)
KONDO AKIHIKO (JP)
UEDA MASAKAZU (JP)
SENO MASAHARU (JP)
TADA HIROKO (JP)
TANIZAWA KATSUYUKI (JP)
KONDO AKIHIKO (JP)
UEDA MASAKAZU (JP)
SENO MASAHARU (JP)
TADA HIROKO (JP)
Application Number:
PCT/JP2003/002602
Publication Date:
October 09, 2003
Filing Date:
March 05, 2003
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
KURODA SHUNICHI (JP)
TANIZAWA KATSUYUKI (JP)
KONDO AKIHIKO (JP)
UEDA MASAKAZU (JP)
SENO MASAHARU (JP)
TADA HIROKO (JP)
KURODA SHUNICHI (JP)
TANIZAWA KATSUYUKI (JP)
KONDO AKIHIKO (JP)
UEDA MASAKAZU (JP)
SENO MASAHARU (JP)
TADA HIROKO (JP)
International Classes:
C12N15/09; A61K9/50; A61K35/12; A61K35/64; A61K35/76; A61K36/06; A61K38/00; A61K38/02; A61K38/21; A61K38/22; A61K39/29; A61P1/16; A61P35/00; B82Y5/00; C07K14/02; A61K48/00; (IPC1-7): A61K48/00; A61K45/00; A61K9/51; A61K9/08; A61K38/18; A61K38/21; A61P1/16; A61P35/00
Domestic Patent References:
| WO2001064930A1 | 2001-09-07 |
Foreign References:
| EP0201416A1 | 1986-11-12 |
Other References:
MASARU MURAOKA ET AL.: "Drug delivery o mezashita tokui-sei kaihen-gata B-gata haien hyomen kogen chuku nano ryushi no kaihatsu", KAGAKU KOGAKKAI NENKAI KENKYU HAPPYO KOEN YOSHISHU (L304), vol. 68, 23 February 2003 (2003-02-23), pages 443, XP002970065
SHUN'ICHI KURODA ET AL.: "Bionano ryushi o mochiiru atarashii idenshi donyu-ho no kaihatsu to sentan iryo eno oyo", MATERIALS INTEGRATION, vol. 15, no. 7, July 2002 (2002-07-01), pages 12 - 17, XP002970066
TADANORI YAMADA ET AL.: "B-gata haien virus hyomen kogen nano ryushi o mochiita atarashii idenshi donyu-ho no kaihatsu", KAGAKU KOGAKKAI NENKAI KENKYU HAPPYO KOEN YOSHISHU (307), vol. 66, 2 March 2001 (2001-03-02), pages 271, XP002970067
DELPEYROUX F. ET AL.: "Insertion in the hepatitis B surface antigen. Effect on assembly and secretion of 22-nm particles from mammalian cells", J. MOL. BIOL., vol. 195, no. 2, 1987, pages 343 - 350, XP002937463
VALENZUELA P. ET AL.: "Antigen engineering in yeast: synthesis and assembly of hybrid hepatitis B surface antigen-herpes simplex 1 gD particles", BIO/TECHNOLOGY, vol. 3, no. 4, 1985, pages 323 - 326, XP002970068
VALENZUELA P. ET AL.: "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast", NATURE, vol. 298, no. 5872, 1982, pages 347 - 350, XP002970069
KURODA S. ET AL.: "Hepatitis B virus envelope L protein particles", J. BIOL. CHEM., vol. 267, no. 3, 1992, pages 1953 - 1961, XP002937464
PUMPENS P. ET AL.: "Hepatitis B core particles as a universal display model: a structure-function basis for development", FEBS LETTERS, vol. 442, 1999, pages 1 - 6, XP000925829
HANENBERG H. ET AL.: "Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells", NAT. MED., vol. 2, no. 8, 1996, pages 876 - 882, XP000916458
SHUN'ICHI KURODA ET AL.: "Bionano ryushi o mochiiru atarashii idenshi donyu-ho no kaihatsu to sentan iryo eno oyo", MATERIALS INTEGRATION, vol. 15, no. 7, July 2002 (2002-07-01), pages 12 - 17, XP002970066
TADANORI YAMADA ET AL.: "B-gata haien virus hyomen kogen nano ryushi o mochiita atarashii idenshi donyu-ho no kaihatsu", KAGAKU KOGAKKAI NENKAI KENKYU HAPPYO KOEN YOSHISHU (307), vol. 66, 2 March 2001 (2001-03-02), pages 271, XP002970067
DELPEYROUX F. ET AL.: "Insertion in the hepatitis B surface antigen. Effect on assembly and secretion of 22-nm particles from mammalian cells", J. MOL. BIOL., vol. 195, no. 2, 1987, pages 343 - 350, XP002937463
VALENZUELA P. ET AL.: "Antigen engineering in yeast: synthesis and assembly of hybrid hepatitis B surface antigen-herpes simplex 1 gD particles", BIO/TECHNOLOGY, vol. 3, no. 4, 1985, pages 323 - 326, XP002970068
VALENZUELA P. ET AL.: "Synthesis and assembly of hepatitis B virus surface antigen particles in yeast", NATURE, vol. 298, no. 5872, 1982, pages 347 - 350, XP002970069
KURODA S. ET AL.: "Hepatitis B virus envelope L protein particles", J. BIOL. CHEM., vol. 267, no. 3, 1992, pages 1953 - 1961, XP002937464
PUMPENS P. ET AL.: "Hepatitis B core particles as a universal display model: a structure-function basis for development", FEBS LETTERS, vol. 442, 1999, pages 1 - 6, XP000925829
HANENBERG H. ET AL.: "Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells", NAT. MED., vol. 2, no. 8, 1996, pages 876 - 882, XP000916458
Attorney, Agent or Firm:
Hara, Kenzo (Daiwa Minamimorimachi Building 2-6,
Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, JP)
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