Title:
DSP-18 DUAL-SPECIFICITY PHOSPHATASE
Document Type and Number:
WIPO Patent Application WO2003025196
Kind Code:
A3
Abstract:
Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and/or cell survival. In particular, the dual-specificity phosphatase DSP-18 isoforms DSP-18a-f, and polypeptide variants thereof that stimulate dephosphorylation of DSP-18 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-18 activity. The polypeptides and agents may be used to modulate cell proliferation, cell differentiation and cell survival.
Inventors:
LUCHE RALF M (US)
WEI BO (US)
WEI BO (US)
Application Number:
PCT/US2002/015906
Publication Date:
February 05, 2004
Filing Date:
May 16, 2002
Export Citation:
Assignee:
CEPTYR INC (US)
LUCHE RALF M (US)
WEI BO (US)
LUCHE RALF M (US)
WEI BO (US)
International Classes:
C12N9/16; (IPC1-7): A61K39/395; A61K38/51; C12P21/06; C12N9/16; C12N1/20; C12N15/00; C07H21/04; C07K1/00; C07K16/00
Domestic Patent References:
| WO2001046394A2 | 2001-06-28 | |||
| WO2001002581A1 | 2001-01-11 |
Foreign References:
| US20030092114A1 | 2003-05-15 |
Other References:
DATABASE GENBANK [online] 28 February 2003 (2003-02-28), TANAI ET AL., XP002972784, Database accession no. (Q9H1R2)
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