DUAL-ACTIVITY NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS

WIPO Patent Application WO/2018/085379

A3

The present disclosure describes NAMPT modulatory compounds, and methods of identifying NAMPT modulatory compounds. The present disclosure also describes methods of testing NAMPT modulatory compounds for NTPase activity, cell mobility modulatory activity, and cell metastasis modulatory activity.

WO/2016/195072	THERAPEUTIC AGENT FOR DRY EYE CHARACTERIZED BY BEING TO BE DROPPED INTO EYE OF DRY EYE PATIENT WEARING SOFT CONTACT LENS
JP2023546316	Multivalent STING activation composition and its use
WO/2020/113812	NADH-CONTAINING BIOLOGICAL HIGH-MOLECULAR-WEIGHT NANOSPHERE, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF

GARDELL STEPHEN (US)
DISPAGNA MAURO (US)

PCT/US2017/059508

June 28, 2018

November 01, 2017

Click for automatic bibliography generation  

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST (US)

A61K31/7084; G01N30/72

WO2012150952A1	2012-11-08
WO2013170191A1	2013-11-14

BURGOS ET AL.: "Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase", BIOCHEMISTRY, vol. 47, 30 September 2008 (2008-09-30), pages 11086 - 11096, XP055495736
BURGOS ET AL.: "A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT", PNAS, vol. 106, 18 August 2009 (2009-08-18), pages 13748 - 13753, XP055495738
AMICI ET AL.: "Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases", CELL CHEMICAL BIOLOGY, vol. 24, 18 May 2017 (2017-05-18), pages 553 - 564, XP055495739

AMODEO, Gabriele, A. et al. (US)

View/Download PDF      PDF Help

Previous Patent: LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS

Next Patent: LEUCO POLYMERS AS BLUING AGENTS IN LAUNDRY CARE COMPOSITIONS