Title:
DUAL SPECIFICALLY PHOSPHATASE AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO1999002704
Kind Code:
A3
Abstract:
PTEN proteins and altered PTEN proteins, and the nucleic acid molecules encoding them are described. Also described are methods of diagnosis and treatment, e.g., of prostate cancer, utilizing compositions comprising PTEN or altered PTEN or nucleic acid molecules encoding PTEN or altered PTEN.
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Inventors:
TONKS NICHOLAS K (US)
MYERS MICHAEL P (US)
MYERS MICHAEL P (US)
Application Number:
PCT/US1998/014205
Publication Date:
April 01, 1999
Filing Date:
July 08, 1998
Export Citation:
Assignee:
COLD SPRING HARBOR LAB (US)
TONKS NICHOLAS K (US)
MYERS MICHAEL P (US)
TONKS NICHOLAS K (US)
MYERS MICHAEL P (US)
International Classes:
C12N9/16; C12N15/55; A61K38/00; (IPC1-7): C12N15/55; A61K31/70; A61K38/46; C07K16/40; C12N9/16; C12Q1/42; C12Q1/68; G01N33/53
Domestic Patent References:
| WO1997015686A1 | 1997-05-01 | |||
| WO1998034624A1 | 1998-08-13 | |||
| WO1998033907A1 | 1998-08-06 |
Other References:
LI, J. ET AL.: "PTEN, a putative tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.", SCIENCE, vol. 275, 28 March 1997 (1997-03-28), pages 1943 - 1946, XP002066155
LI, D-M. ET AL.: "TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.", CANCER RESEARCH, vol. 57, 1 June 1997 (1997-06-01), pages 2124 - 2129, XP002066157
STECK, P.A. ET AL.: "Identification of a candidate tumor suppressor gene at 10q23.3 that is mutated in multiple advanced cancers, MMAC1.", NATURE GENETICS, vol. 15, April 1997 (1997-04-01), pages 356 - 363, XP002066156
PAYRASTRE, B. ET AL.: "Phosphoinositide 3-phosphatase segregates from phosphatidylinositol 3-kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse phosphatidylinositol(3,4,5)trisphosphate.", FEBS LETTERS, vol. 341, 1994, pages 113 - 8, XP002088256
ZHOU, G. ET AL.: "The catalytic role of Cys124 in the dual specificity phosphatase VHR.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 45, 11 November 1994 (1994-11-11), pages 28084 - 90, XP002088257
MYERS, M. ET AL.: "P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatse.", PROC.NATL.ACAD.SCI.USA, vol. 94, August 1997 (1997-08-01), XP002088258
MAEHAMA, T. ET AL.: "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 22, 29 May 1998 (1998-05-29), pages 13375 - 8, XP002088259
LI, D-M. ET AL.: "TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.", CANCER RESEARCH, vol. 57, 1 June 1997 (1997-06-01), pages 2124 - 2129, XP002066157
STECK, P.A. ET AL.: "Identification of a candidate tumor suppressor gene at 10q23.3 that is mutated in multiple advanced cancers, MMAC1.", NATURE GENETICS, vol. 15, April 1997 (1997-04-01), pages 356 - 363, XP002066156
PAYRASTRE, B. ET AL.: "Phosphoinositide 3-phosphatase segregates from phosphatidylinositol 3-kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse phosphatidylinositol(3,4,5)trisphosphate.", FEBS LETTERS, vol. 341, 1994, pages 113 - 8, XP002088256
ZHOU, G. ET AL.: "The catalytic role of Cys124 in the dual specificity phosphatase VHR.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 45, 11 November 1994 (1994-11-11), pages 28084 - 90, XP002088257
MYERS, M. ET AL.: "P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatse.", PROC.NATL.ACAD.SCI.USA, vol. 94, August 1997 (1997-08-01), XP002088258
MAEHAMA, T. ET AL.: "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-triphosphate.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 22, 29 May 1998 (1998-05-29), pages 13375 - 8, XP002088259
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