EDARAVONE PRODRUG COMPOUND AND PHARMACEUTICAL USE THEREOF IN TREATMENT OR ALLEVIATION OF NEURODEGENERATIVE OR MOTOR NEURON DISEASE

Title:

EDARAVONE PRODRUG COMPOUND AND PHARMACEUTICAL USE THEREOF IN TREATMENT OR ALLEVIATION OF NEURODEGENERATIVE OR MOTOR NEURON DISEASE

Document Type and Number:

WIPO Patent Application WO/2020/060092

Kind Code:

A1

Abstract:

The present invention provides a novel prodrug of an edaravone compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising same as an active ingredient, and a use thereof in treatment or alleviation of neurodegenerative and/or motor neuron disease.

Inventors:

KIM JAE-SUN (KR)
RYU HYUNG-CHUL (KR)
LIM JEE-WOONG (KR)
KANG EUN-BI (KR)
KIM HYUK-MIN (KR)
YANG HYUNJUN (KR)
CHANG DUKHO (KR)
KIM DONG-GYU (KR)
RYOO BYUNGHWAN (KR)
OH YONG-HO (KR)

Application Number:

PCT/KR2019/011639

Publication Date:

March 26, 2020

Filing Date:

September 09, 2019

Export Citation:

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Assignee:

J2H BIOTECH INC (KR)
THERAGEN ETEX CO LTD (KR)

International Classes:

C07D231/20; A61K31/496; A61P25/28

Domestic Patent References:

WO2018133621A1	2018-07-26
WO2002092082A1	2002-11-21

Foreign References:

CN102190622A	2011-09-21
US20150080364A1	2015-03-19
CN104098512A	2014-10-15
CN102190622A	2011-09-21

Other References:

FRONTIERS IN AGING NEUROSCIENCE, vol. 9, 2017, pages 68
PROCCEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 112, no. 16, 2015, pages 5225
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
"Remington : The Science and Practice of Pharmacy", 1995, MACK PUBLISHING
BLAUG, SEYMOUR: "Remington's Pharmaceutical Science", 1975, MACK PUBLISHING COMPANY
See also references of EP 3854787A4

Attorney, Agent or Firm:

PHIL & ONZI INT'L PATENT & LAW FIRM (KR)

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