Title:
EDIBLE COMPOSITION HAVING EFFECTS OF PROMOTING THE PRODUCTION AND RELEASE OF CALCITONIN GENE-RELATED PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2005/099686
Kind Code:
A1
Abstract:
An edible composition having effects of promoting the production and release of a calcitonin gene-related peptide. Namely, an edible composition comprising isoflavone and capsaicin as the essential components and having effects of promoting the production and release of a calcitonin gene-related peptide; and an edible composition comprising the above-described edible composition for preventing and treating gastric mucosal injury, life style-related diseases, obesity, malignant tumor and osteoporosis, relieving rejection accompanying organ transplantation, preventing and relieving organ injury caused by vital invasion reactions against invasive factors such as infection, and stimulating hair (for example, head hair) growth. This edible composition exerts effects of preventing and treating gastric mucosal injury and so on and these effects are mild without any risk of side effect.
Inventors:
OKAJIMA KENJI (JP)
TODA TOSHIYA (JP)
TODA TOSHIYA (JP)
Application Number:
PCT/JP2005/003839
Publication Date:
October 27, 2005
Filing Date:
March 01, 2005
Export Citation:
Assignee:
FUJICCO CO LTD (JP)
OKAJIMA KENJI (JP)
TODA TOSHIYA (JP)
OKAJIMA KENJI (JP)
TODA TOSHIYA (JP)
International Classes:
A23L1/30; A61K31/165; A61K31/352; A61P1/04; A61P3/04; A61P17/14; A61P19/10; A61P35/00; A61P37/06; A61P43/00; C07D311/36; (IPC1-7): A61K31/352; A23L1/30; A61K31/165; A61K35/78; A61P1/04; A61P3/04; A61P17/14; A61P19/10; A61P35/00; A61P37/06; A61P43/00; C07D311/36
Domestic Patent References:
| WO2000059523A1 | 2000-10-12 |
Foreign References:
| JP2005068129A | 2005-03-17 | |||
| EP1329222A1 | 2003-07-23 | |||
| JP2003286180A | 2003-10-07 | |||
| JP2002275062A | 2002-09-25 | |||
| JP2004059454A | 2004-02-26 |
Other References:
BAXA D.M. ET AL: "Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha.", BIOCHEMICAL PHARMACOLOGY., vol. 66, 2003, pages 1009 - 1018, XP002989167
SINGH S. ET AL: "Capsaicin (8-Methyl-N-Vanillyl-6-Nonenamide) Is a Potent Inhibitor of Nuclear Transcription Factor-KappaB Activator by Diverse Agents.", THE JOURNAL OF IMMUNOLOGY., vol. 157, no. 10, 1996, pages 4412 - 4420, XP002989168
INOUE D. AND MATSUMOTO T. ET AL: "Hone Taisha Kiso Kenkyu no Shinpo.", JAPANESE JOURNAL OF CLINICAL MEDICINE., vol. 60, 28 March 2002 (2002-03-28), pages 25 - 33, XP002992643
HARADA N. ET AL: "Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.", AM J PHYSIOL., vol. 285, December 2003 (2003-12-01), pages G1214 - G1224, XP002989169
VIGNERY A. ET AL: "The Neuropeptide Calcitonin Gene-Related Peptide Stimulates Insulin-like Growth Factor I Production by Primary Fetal Rat Osteoblasts.", BONE., vol. 18, no. 4, April 1996 (1996-04-01), pages 331 - 335, XP002065011
MILLET I. ET AL: "Inhibition of NF-kappaB Activity and Enhancement of Apoptosis by the Neuropeptide Calcitonin Gene-related Peptide.", THE JOURNAL OF BIOLOGICAL CHEMSITRY., vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 15114 - 15121, XP002989170
PHILPOTT M.P. ET AL: "Effects of Insulin and Insulin-Like Growth Factors on Cultured Human Hair Follicles: IGF-I at Physiologic Concentrations is an Important Regulator of Hairfollicle Growth in Vitro.", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY., vol. 102, 1994, pages 857 - 861, XP001095971
SINGH S. ET AL: "Capsaicin (8-Methyl-N-Vanillyl-6-Nonenamide) Is a Potent Inhibitor of Nuclear Transcription Factor-KappaB Activator by Diverse Agents.", THE JOURNAL OF IMMUNOLOGY., vol. 157, no. 10, 1996, pages 4412 - 4420, XP002989168
INOUE D. AND MATSUMOTO T. ET AL: "Hone Taisha Kiso Kenkyu no Shinpo.", JAPANESE JOURNAL OF CLINICAL MEDICINE., vol. 60, 28 March 2002 (2002-03-28), pages 25 - 33, XP002992643
HARADA N. ET AL: "Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.", AM J PHYSIOL., vol. 285, December 2003 (2003-12-01), pages G1214 - G1224, XP002989169
VIGNERY A. ET AL: "The Neuropeptide Calcitonin Gene-Related Peptide Stimulates Insulin-like Growth Factor I Production by Primary Fetal Rat Osteoblasts.", BONE., vol. 18, no. 4, April 1996 (1996-04-01), pages 331 - 335, XP002065011
MILLET I. ET AL: "Inhibition of NF-kappaB Activity and Enhancement of Apoptosis by the Neuropeptide Calcitonin Gene-related Peptide.", THE JOURNAL OF BIOLOGICAL CHEMSITRY., vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 15114 - 15121, XP002989170
PHILPOTT M.P. ET AL: "Effects of Insulin and Insulin-Like Growth Factors on Cultured Human Hair Follicles: IGF-I at Physiologic Concentrations is an Important Regulator of Hairfollicle Growth in Vitro.", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY., vol. 102, 1994, pages 857 - 861, XP001095971
Attorney, Agent or Firm:
Saitoh, Yukihiko (2-7 Minamimorimachi 2-chome, Kita-k, Osaka-shi Osaka, JP)
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