EFFECT OF GROWTH HORMONE AND IGF-1 ON NEURAL STEM CELLS AND THERAPEUTIC APPLICATION

WIPO Patent Application WO2003024471

A3

The present invention provides a method of increasing neural stem cell numbers by using growth hormone and/or IGF-l. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions.

WEISS SAMUEL (CA)
SHINGO TETSURO (JP)

PCT/CA2002/001344

August 21, 2003

August 30, 2002

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STEM CELL THERAPEUTICS INC (CA)
WEISS SAMUEL (CA)
SHINGO TETSURO (JP)

A61K38/22; A61K38/27; A61K38/30; A61P25/00; C12N5/0797; A61K35/12; (IPC1-7): C12N5/06; C12N5/08; A61K38/30; A61K38/27; A61K35/30; A61P25/00

WO2000013650A2	2000-03-16
WO1999051272A1	1999-10-14

GAGE FRED H: "Mammalian neural stem cells.", SCIENCE (WASHINGTON D C)., vol. 287, no. 5457, 25 February 2000 (2000-02-25), pages 1433 - 1438, XP002220467, ISSN: 0036-8075
ARSENIJEVIC YVAN ET AL: "Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2.", JOURNAL OF NEUROSCIENCE, vol. 21, no. 18, 15 September 2001 (2001-09-15), pages 7194 - 7202, XP002220612, ISSN: 0270-6474

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