Title:
EFFECTOR DOMAINS FOR CRISPR-CAS SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2023/200998
Kind Code:
A3
Abstract:
Disclosed herein are effector domains. The effector domains may be used with, for example, Cas proteins and CRISPR-Cas systems. The effectors may be used in combination with a Cas protein to form a fusion protein. The effectors may also be used in combination with an antibody that binds to a peptide epitope, wherein the peptide epitope is fused to a Cas protein. The compositions and methods comprising the effectors may be used to modulate gene expression.
Inventors:
GERSBACH CHARLES A (US)
BUTTERFIELD GABRIEL (US)
ROHM DAHLIA (US)
IGLESIAS NAHID (US)
BUTTERFIELD GABRIEL (US)
ROHM DAHLIA (US)
IGLESIAS NAHID (US)
Application Number:
PCT/US2023/018559
Publication Date:
November 23, 2023
Filing Date:
April 13, 2023
Export Citation:
Assignee:
UNIV DUKE (US)
International Classes:
C07K19/00; A61P21/00; C12N9/22; C12N15/85; C12N15/113
Domestic Patent References:
| WO2022032397A1 | 2022-02-17 | |||
| WO2022133062A1 | 2022-06-23 |
Foreign References:
| US20190127713A1 | 2019-05-02 |
Other References:
PICKAR-OLIVER ET AL.: "The next generation of CRISPR-Cas technologies and applications", NATURE REVIEWS MOLECULAR CELL BIOLOGY, vol. 20, no. 8, 30 May 2019 (2019-05-30), pages 490 - 507, XP037038726, DOI: 10.1038/s41580-019-0131-5
Attorney, Agent or Firm:
COX, Julia M. et al. (US)
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