EFFECTS OF COMBINED ADMINISTRATION OF FARNESYL TRANSFERASE INHIBITORS AND SIGNAL TRANSDUCTION INHIBITORS

Title:

EFFECTS OF COMBINED ADMINISTRATION OF FARNESYL TRANSFERASE INHIBITORS AND SIGNAL TRANSDUCTION INHIBITORS

Document Type and Number:

WIPO Patent Application WO2002028409

Kind Code:

A3

Abstract:

The present invention relates to methods of reducing proliferation of cells, enhancing apoptosis of cells or both in an individual in need thereof, comprising administering to the individual a combination of at least one farnesyl transferase inhibitor (FTI), such as an inhibitor or Ras function, and at least one signal transduction inhibitor (STI) in a therapeutically effective amount, wherein proliferation of cells is reduced and/or apoptosis of cells in enhanced in the individual. In one embodiment, the invention relates to a method of reducing proliferation of STI resistants cells, enhancing apoptosis of STI resistant cells, or both in an individual in need thereof, comprising administering to the individual a combination of at least one FTI and at least one STI in a therapeutically effective amount, wherein proliferation of STI resistant cells is reduced and/or apoptosis of STI resistant cells is enhanced in the individual. The present invention can be used to treat leukemia (e.g., CML) in an individual comprising administering to the individual a combination of at least one FTI and at least one STI in a therapeutically effective amount.

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Inventors:

DALEY GEORGE Q (US)
HOOVER RUSSELL R (US)

Application Number:

PCT/US2001/031104

Publication Date:

March 06, 2003

Filing Date:

October 04, 2001

Export Citation:

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Assignee:

WHITEHEAD BIOMEDICAL INST (US)
DALEY GEORGE Q (US)
HOOVER RUSSELL R (US)

International Classes:

A61K31/473; A61K31/495; A61K45/06; A61P35/02; (IPC1-7): A61K45/06; A61P35/02

Domestic Patent References:

WO1997045412A1	1997-12-04
WO2000061145A1	2000-10-19
WO1998057948A1	1998-12-23
WO1998057945A1	1998-12-23
WO2000042042A2	2000-07-20

Other References:

COX A C ET AL: "FARNESYLTRANSFERASE INHIBITORS AND CANCER TREATMENT: TARGETING SIMPLY RAS?", BBA - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1333, no. 1, 1997, pages F51 - F71, XP000944880, ISSN: 0304-419X

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