Title:
EFFICIENT METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2021/251466
Kind Code:
A1
Abstract:
The present invention provides: a method that is for improving establishing efficiency of iPS cells and that includes, in a nuclear reprogramming step for somatic cells, inhibiting the function of transcription enhancer factor domain family member-3 (TEAD3); and a method that is for producing iPS cells and that includes bringing somatic cells into contact with nuclear reprogramming substances and a substance for inhibiting the function of TEAD3.
Inventors:
YOSHIDA YOSHINORI (JP)
LUCENA-CACACE ANTONIO (JP)
LUCENA-CACACE ANTONIO (JP)
Application Number:
PCT/JP2021/022154
Publication Date:
December 16, 2021
Filing Date:
June 10, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N15/113; C12N5/0735; C12N5/10; C12N15/115; C12N15/12
Domestic Patent References:
| WO2014097875A1 | 2014-06-26 |
Other References:
IAN LIAN, KIM JOUNGMOK, OKAZAWA HIDEKI, ZHAO JIAGANG, ZHAO BIN, YU JINDAN, CHINNAIYAN ARUL, ISRAEL MASON A, GOLDSTEIN LAWRENCE S B: "The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation", GENES & DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, 1 June 2010 (2010-06-01), pages 1106 - 1118, XP055240649, Retrieved from the Internet [retrieved on 20160112], DOI: 10.1101/gad.1903310
TAMM CHRISTOFFER, BÖWER NATHALIE, ANNERÉN CECILIA: "Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 124, no. 7, 1 April 2011 (2011-04-01), Cambridge , pages 1136 - 1144, XP055885341, ISSN: 0021-9533, DOI: 10.1242/jcs.075796
HAN ZHENBO, YU YING, CAI BENZHI, XU ZIHANG, BAO ZHENGYI, ZHANG YING, BAMBA DJIBRIL, MA WENYA, GAO XINLU, YUAN YE, ZHANG LAI, YU ME: "YAP/TEAD3 signal mediates cardiac lineage commitment of human‐induced pluripotent stem cells", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 235, no. 3, 1 March 2020 (2020-03-01), US , pages 2753 - 2760, XP055885345, ISSN: 0021-9541, DOI: 10.1002/jcp.29179
TAMM CHRISTOFFER, BÖWER NATHALIE, ANNERÉN CECILIA: "Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF", JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LIMITED, CAMBRIDGE, vol. 124, no. 7, 1 April 2011 (2011-04-01), Cambridge , pages 1136 - 1144, XP055885341, ISSN: 0021-9533, DOI: 10.1242/jcs.075796
HAN ZHENBO, YU YING, CAI BENZHI, XU ZIHANG, BAO ZHENGYI, ZHANG YING, BAMBA DJIBRIL, MA WENYA, GAO XINLU, YUAN YE, ZHANG LAI, YU ME: "YAP/TEAD3 signal mediates cardiac lineage commitment of human‐induced pluripotent stem cells", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 235, no. 3, 1 March 2020 (2020-03-01), US , pages 2753 - 2760, XP055885345, ISSN: 0021-9541, DOI: 10.1002/jcp.29179
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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