Title:
EGFR DEGRADERS AND ASSOCIATED METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2022/227032
Kind Code:
A1
Abstract:
Provided herein is a method for preparing novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation.
Inventors:
LEI BAILIN (CN)
LIU HUAQING (CN)
HAN SONGZHE (CN)
WANG ZHIWEI (CN)
LIU HUAQING (CN)
HAN SONGZHE (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2021/091590
Publication Date:
November 03, 2022
Filing Date:
April 30, 2021
Export Citation:
Assignee:
BEIGENE BEIJING CO LTD (CN)
International Classes:
C07D401/12; C07F9/6509; C07F9/6558; C07F9/6584
Domestic Patent References:
| WO2020253862A1 | 2020-12-24 | |||
| WO2012051587A1 | 2012-04-19 |
Foreign References:
| US20140066406A1 | 2014-03-06 |
Other References:
PÁV ONDŘEJ; BUDĚŠÍNSKÝ MILOŠ; ROSENBERG IVAN: "Novel phosphanucleoside analogs of dideoxynucleosides", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 73, no. 34, 24 August 2017 (2017-08-24) - 14 July 2017 (2017-07-14), AMSTERDAM, NL , pages 5220 - 5228, XP085144659, ISSN: 0040-4020, DOI: 10.1016/j.tet.2017.07.020
LIM KELVIN MENG-HUI, HAYASHI TAMIO: "Dynamic Kinetic Resolution in Rhodium-Catalyzed Asymmetric Arylation of Phospholene Oxides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 24, 21 June 2017 (2017-06-21), pages 8122 - 8125, XP055982621, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04570
LIM KELVIN MENG-HUI, HAYASHI TAMIO: "Dynamic Kinetic Resolution in Rhodium-Catalyzed Asymmetric Arylation of Phospholene Oxides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 139, no. 24, 21 June 2017 (2017-06-21), pages 8122 - 8125, XP055982621, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04570
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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