Title:
EGFR DEGRADERS AND ASSOCIATED METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2022/228556
Kind Code:
A1
Abstract:
Provided herein are novel bifunctional compounds formed by conjugating EGFR inhibitor moieties with E3 ligase Ligand moieties, which function to recruit targeted proteins to E3 ubiquitin ligase for degradation. It also provides pharmaceutically acceptable compositions comprising compounds and methods for the treatment of EGFR mutant-related cancers.
Inventors:
LEI BAILIN (CN)
LIU HUAQING (CN)
HAN SONGZHE (CN)
WANG ZHIWEI (CN)
LIU HUAQING (CN)
HAN SONGZHE (CN)
WANG ZHIWEI (CN)
Application Number:
PCT/CN2022/090342
Publication Date:
November 03, 2022
Filing Date:
April 29, 2022
Export Citation:
Assignee:
BEIGENE LTD (GB)
LEI BAILIN (CN)
LEI BAILIN (CN)
International Classes:
C07D401/14; A61K31/506; A61P35/00; C07D401/04
Domestic Patent References:
| WO2022068849A1 | 2022-04-07 | |||
| WO2022012623A1 | 2022-01-20 | |||
| WO2022012622A1 | 2022-01-20 | |||
| WO2021036922A1 | 2021-03-04 |
Foreign References:
| CN103153064A | 2013-06-12 | |||
| CN102105150A | 2011-06-22 | |||
| CN110753693A | 2020-02-04 | |||
| CN109912655A | 2019-06-21 | |||
| CN109928956A | 2019-06-25 | |||
| CN110684015A | 2020-01-14 |
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
Download PDF:
Previous Patent: POLYMER AND COMPOSITION THEREOF
Next Patent: METHOD AND APPARATUS FOR SEARCHING FOR CLIPPING TEMPLATE
Next Patent: METHOD AND APPARATUS FOR SEARCHING FOR CLIPPING TEMPLATE