Title:
EGFRVIII-SPECIFIC APTAMER AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/177246
Kind Code:
A1
Abstract:
The present invention relates to an epidermal growth factor receptor variant III (EGFRvIII) specific aptamer and to the detection of EGFRvIII or the diagnosis of cancer using same. Since the aptamer of the present invention binds to EGFRvIII with high affinity, the aptamer can be applied to detect EGFRvIII or diagnose EGFRvIII-expressing cancer.
Inventors:
KIM YOUNDONG (KR)
LEE DAEKYUN (KR)
SHIN EUISU (KR)
KANG JUHYUNG (KR)
LEE DASOM (KR)
LEE DAEKYUN (KR)
SHIN EUISU (KR)
KANG JUHYUNG (KR)
LEE DASOM (KR)
Application Number:
PCT/KR2023/003554
Publication Date:
September 21, 2023
Filing Date:
March 17, 2023
Export Citation:
Assignee:
APTAMER SCIENCES INC (KR)
International Classes:
C12N15/115; C12Q1/6886
Foreign References:
| KR101680335B1 | 2016-11-28 | |||
| KR20130003071A | 2013-01-09 | |||
| US10221421B2 | 2019-03-05 | |||
| KR20220001481A | 2022-01-05 |
Other References:
ZAVYALOVA ELENA, TURASHEV ASKAR, NOVOSELTSEVA ANASTASIA, LEGATOVA VALERIIA, ANTIPOVA OLGA, SAVCHENKO EKATERINA, BALK SONJA, GOLOVI: "Pyrene-Modified DNA Aptamers with High Affinity to Wild-Type EGFR and EGFRvIII", NUCLEIC ACID THERAPEUTICS, MARY ANN LIEBERT, INC. PUBLISHERS, US, vol. 30, no. 3, 1 June 2020 (2020-06-01), US , pages 175 - 187, XP093093041, ISSN: 2159-3337, DOI: 10.1089/nat.2019.0830
WU XIDONG, LIANG HUIYU, TAN YAN, YUAN CHAO, LI SHUJI, LI XIAOWEN, LI GUIPING, SHI YUSHENG, ZHANG XINGMEI: "Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo", PLOS ONE, vol. 9, no. 3, pages e90752, XP093093043, DOI: 10.1371/journal.pone.0090752
WU XIDONG, LIANG HUIYU, TAN YAN, YUAN CHAO, LI SHUJI, LI XIAOWEN, LI GUIPING, SHI YUSHENG, ZHANG XINGMEI: "Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo", PLOS ONE, vol. 9, no. 3, pages e90752, XP093093043, DOI: 10.1371/journal.pone.0090752
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY & LAW (KR)
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