Title:
EICOSAPENTAENOIC ACID ALKYL ESTER-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2020/138282
Kind Code:
A1
Abstract:
The present invention provides an eicosapentaenoic acid-containing composition having high concentration and high purity. A method for producing an eicosapentaenoic acid alkyl ester-containing composition, which comprises (1) a process wherein a starting material oil containing an eicosapentaenoic acid alkyl ester is brought into contact with an aqueous solution containing a silver salt, and subsequently an aqueous layer is recovered, (2) a process wherein an organic solvent is added to the aqueous layer, and subsequently an organic solvent layer is recovered, and (3) a process wherein the organic solvent layer is subjected to vacuum distillation at a temperature of 180-188°C at a column top vacuum degree of 0.7 Pa or less, thereby recovering the eicosapentaenoic acid alkyl ester from the organic solvent layer.
Inventors:
GOTO ICHIRO (JP)
HARATA MASATAKA (JP)
NONAKA SHINGO (JP)
HARATA MASATAKA (JP)
NONAKA SHINGO (JP)
Application Number:
PCT/JP2019/051107
Publication Date:
July 02, 2020
Filing Date:
December 26, 2019
Export Citation:
Assignee:
NISSHIN PHARMA INC (JP)
International Classes:
C07C69/587; C11B3/12
Domestic Patent References:
| WO2014054435A1 | 2014-04-10 | |||
| WO2013172346A1 | 2013-11-21 | |||
| WO2016043251A1 | 2016-03-24 | |||
| WO2014054435A1 | 2014-04-10 | |||
| WO2017191821A1 | 2017-11-09 |
Foreign References:
| JP2016502573A | 2016-01-28 | |||
| JP2015105354A | 2015-06-08 | |||
| JP2786748B2 | 1998-08-13 | |||
| JP2895258B2 | 1999-05-24 | |||
| JP2935555B2 | 1999-08-16 | |||
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Other References:
IPID FARDIN-KIA ALI REZA; DELMONTE PIERLUIGI; KRAMER JOHN K; JAHREIS GERHARD; KUHNT KATRIN; SANTERCOLE VIVIANA; RADER JEANNE I: "Separation of the Fatty Acids in Menhaden Oil as Methyl Esters with a Highly Polar Ionic Liquid Gas Chromatographic Column and Identification by Time of Flight Mass spectrometry", LIPIDS, vol. 48, no. 12, 2013, pages 1279 - 1295, XP035364675, ISSN: 0024-4201, DOI: 10.1007/s11745-013-3830-2
ERKKI SIPPOLA , FRANK DAVID , PAT SANDRA: "Temperature program optimization by computer simulation for the capillary GC analysis of fatty acid methyl esters on biscyanopropyl siloxane phases", JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, vol. 16, no. 2, 1 February 1993 (1993-02-01), pages 95 - 100, XP055722125, DOI: 10.1002/jhrc.1240160206
See also references of EP 3904328A4
ERKKI SIPPOLA , FRANK DAVID , PAT SANDRA: "Temperature program optimization by computer simulation for the capillary GC analysis of fatty acid methyl esters on biscyanopropyl siloxane phases", JOURNAL OF HIGH RESOLUTION CHROMATOGRAPHY, vol. 16, no. 2, 1 February 1993 (1993-02-01), pages 95 - 100, XP055722125, DOI: 10.1002/jhrc.1240160206
See also references of EP 3904328A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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