Title:
EMBOLIC MATERIALS COMPRISING OF CHITIN AND/OR CHITOSAN AND METHOD FOR PREPARING THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/013552
Kind Code:
A1
Abstract:
The invention relates to embolic materials used for embolization of blood vessels by inserting a catheter into the blood vessel and injecting the embolic materials through the catheter, and a method for preparing thereof. The embolic materials of this invention are comprised of chitin and/or chitosan particles having an average diameter of 50 to 1000 um and substantially spherical chitosan beads having an average diamter of 50 to 1000 um. The method for preparing chitosan beads comprises the step of making chitosan solution into microdroplet by pressurizing without passing in a capillary under a flowing inert gas stream and making beads by precipitating the above-mentioned microdroplet into coagulation solution. The embolic materials of this invention are substantially spherical and highly biocompatibility blood vessel embolic materials, which enable to embody a perfect embolization with little of foreign body reaction, to absorb and solidify medicinal agents such as contract media for angiography or anticancer agent without passing through a capillary, to be degradable or nondegradable in a blood vessel, to be prepared of a relatively uniform size in specific ranges, which has no oncogenicity and which are more or less inflammatory.
Inventors:
HAN SANG-MUN (KR)
KWAK BYUNG-KOOK (KR)
SHIM HYUNG-JIN (KR)
KWAK BYUNG-KOOK (KR)
SHIM HYUNG-JIN (KR)
Application Number:
PCT/KR2002/001443
Publication Date:
February 20, 2003
Filing Date:
July 30, 2002
Export Citation:
Assignee:
HAN SANG-MUN (KR)
KWAK BYUNG-KOOK (KR)
SHIM HYUNG-JIN (KR)
KWAK BYUNG-KOOK (KR)
SHIM HYUNG-JIN (KR)
International Classes:
A61K31/722; (IPC1-7): A61K31/722
Domestic Patent References:
| WO2001030411A1 | 2001-05-03 | |||
| WO1998003203A1 | 1998-01-29 |
Other References:
NICHIOKA YUTAKA, KYOTANI SHOJIRO: "A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma: embolic effect of cisplatin albumin microspheres using chitin and chitosan in dogs and changes of cisplatin content in blood and tissue", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 40, no. 1, 1992, pages 267 - 268, XP000246013
Attorney, Agent or Firm:
Kim, Chong-yong (2 Floor Insung Building, 437-3, Bangbae-don, Seocho-gu 137-060 Seoul, KR)
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