Title:
EMBRYO IMPLANTATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2004/022082
Kind Code:
A1
Abstract:
To establish pregnancy, it is important that an embryo well communicates with the parent body and thus is allowed to implant in the uterine wall. Clarification and regulation of a factor mediating the embryo-parent body communication, if possible, enable the development of means of treating and preventing disorders such as infertility. On the other hand, it also becomes possible to safely avoid pregnancy thereby. A protein factor having been known as a 10 KDa protein (IP-10) usually induced by interferon &gammad is identified as a factor which participates in the immune process, activation of embryo migration, promotion of embryo implantation in the uterine wall, exertion of the chemotaxis activity, etc. during the period of the implantation of the embryo in the parenteral body and thus controls the implantation of the embryo in the uterine wall. Using this factor, it is possible to develop and provide a remedy for infertility, a pregnant efficiency enhancer, an agent for inducing an embryo into the uterine during the implantation period, an agent controlling the fetal-parenteral body interaction and so on.
Inventors:
IMAKAWA KAZUHIKO (JP)
NAGAOKA KENTARO (JP)
WATANABE FUMIKO (JP)
NAGAOKA KENTARO (JP)
WATANABE FUMIKO (JP)
Application Number:
PCT/JP2003/011268
Publication Date:
March 18, 2004
Filing Date:
September 03, 2003
Export Citation:
Assignee:
PROTEINEXPRESS CO LTD (JP)
IMAKAWA KAZUHIKO (JP)
NAGAOKA KENTARO (JP)
WATANABE FUMIKO (JP)
IMAKAWA KAZUHIKO (JP)
NAGAOKA KENTARO (JP)
WATANABE FUMIKO (JP)
International Classes:
A61K31/7088; A61K38/17; A61P15/00; A61P37/02; C07K14/47; C07K14/52; G01N33/68; (IPC1-7): A61K38/00; A61K48/00; A61K39/395; A61K31/7088; A61P15/00; A61P37/02; C12N15/09; C12Q1/68; G01N33/50; G01N33/15; G01N33/68; G01N33/53
Domestic Patent References:
| WO2001074841A1 | 2001-10-11 | |||
| WO1998058962A1 | 1998-12-30 | |||
| WO1998005323A2 | 1998-02-12 | |||
| WO1994004670A1 | 1994-03-03 | |||
| WO2000047228A1 | 2000-08-17 | |||
| WO1997000691A1 | 1997-01-09 |
Other References:
NAGAOKA K. ET AL.: "Regulation of blastocyst migration, apposition and initial adhesion by a chemokine, interferon gamma-inducible protein 10 kDa (IP-10), during early gestation", J. BIOL. CHEM., vol. 278, no. 31, 1 August 2003 (2003-08-01), pages 29048 - 29056, XP002974991
NAGAOKA K. ET AL.: "A chemokine, interferon(IFN) - gamma-inducible protein 10kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometrium", BIOL. REPROD., vol. 68, no. 4, April 2003 (2003-04-01), pages 1413 - 1421, XP002974992
NAGAOKA ET AL.: "Nishin.chakusho katei no kaimei no mukete", JAPANESE SOCIETY OF VETERINARY SCIENCE GAKUJUTSU SHUKAI KOEN YOSHISHU, vol. 135, no. 24, 25 March 2003 (2003-03-25), pages 24, XP002974993
NAGAOKA ET AL.: "Chakushoki no hitsuji shikyunai no okeru IFN-gamma-inducible protein 10kDa (IP10) chemokine no hatsugen to sono kino", JAPANESE SOCIETY OF VETERINARY SCIENCE GAKUJUTSU SHUKAI KOEN YOSHISHU, vol. 134, no. 73, 20 August 2002 (2002-08-20), XP002974994
KAI K. ET AL.: "Expression of interferon-gamma-inducible protein-10 in human endometrial stromal cells", MOL. HUM. REPROD., vol. 8, no. 2, February 2002 (2002-02-01), pages 176 - 180, XP002974995
ANGIOLILLO A.L. ET AL.: "Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo", J. EXP. MED., vol. 182, no. 1, 1995, pages 155 - 162, XP002916077
WOOD GARY W. ET AL.: "Relative role of CSF-1, MCP-1/JE and RANTES in macrophage recruitment during successful pregnancy", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 46, no. 1, 1997, pages 62 - 70, XP002974996
REZAIE P. ET AL.: "Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS", GLIA, vol. 37, no. 1, January 2002 (2002-01-01), pages 64 - 75, XP002974997
INNGJERDINGEN M. ET AL.: "Expression and regulation of chemokine receptors in human natural killer cells", BLOOD, vol. 97, no. 2, 2001, pages 367 - 375, XP002974998
FARBER J.M. ET AL.: "Mig and IP-10: CXC chemokines that target lymphocytes", J. LEUKOC. BIOL., vol. 61, no. 3, 1997, pages 246 - 257, XP002048973
JINQUAN T. ET AL.: "CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma", J. IMMUNOL., vol. 165, no. 3, 2000, pages 1548 - 1556, XP002974999
CELLA M. ET AL.: "Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon", NAT. MED., vol. 5, no. 8, 1999, pages 919 - 923, XP002243857
LUSTER A.D. ET AL.: "gamma-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins", NATURE, vol. 315, no. 2, 1985, pages 672 - 676, XP002004832
NAGAOKA K. ET AL.: "A chemokine, interferon(IFN) - gamma-inducible protein 10kDa, is stimulated by IFN-tau and recruits immune cells in the ovine endometrium", BIOL. REPROD., vol. 68, no. 4, April 2003 (2003-04-01), pages 1413 - 1421, XP002974992
NAGAOKA ET AL.: "Nishin.chakusho katei no kaimei no mukete", JAPANESE SOCIETY OF VETERINARY SCIENCE GAKUJUTSU SHUKAI KOEN YOSHISHU, vol. 135, no. 24, 25 March 2003 (2003-03-25), pages 24, XP002974993
NAGAOKA ET AL.: "Chakushoki no hitsuji shikyunai no okeru IFN-gamma-inducible protein 10kDa (IP10) chemokine no hatsugen to sono kino", JAPANESE SOCIETY OF VETERINARY SCIENCE GAKUJUTSU SHUKAI KOEN YOSHISHU, vol. 134, no. 73, 20 August 2002 (2002-08-20), XP002974994
KAI K. ET AL.: "Expression of interferon-gamma-inducible protein-10 in human endometrial stromal cells", MOL. HUM. REPROD., vol. 8, no. 2, February 2002 (2002-02-01), pages 176 - 180, XP002974995
ANGIOLILLO A.L. ET AL.: "Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo", J. EXP. MED., vol. 182, no. 1, 1995, pages 155 - 162, XP002916077
WOOD GARY W. ET AL.: "Relative role of CSF-1, MCP-1/JE and RANTES in macrophage recruitment during successful pregnancy", MOLECULAR REPRODUCTION AND DEVELOPMENT, vol. 46, no. 1, 1997, pages 62 - 70, XP002974996
REZAIE P. ET AL.: "Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: Potential role of chemokines in the developing CNS", GLIA, vol. 37, no. 1, January 2002 (2002-01-01), pages 64 - 75, XP002974997
INNGJERDINGEN M. ET AL.: "Expression and regulation of chemokine receptors in human natural killer cells", BLOOD, vol. 97, no. 2, 2001, pages 367 - 375, XP002974998
FARBER J.M. ET AL.: "Mig and IP-10: CXC chemokines that target lymphocytes", J. LEUKOC. BIOL., vol. 61, no. 3, 1997, pages 246 - 257, XP002048973
JINQUAN T. ET AL.: "CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma", J. IMMUNOL., vol. 165, no. 3, 2000, pages 1548 - 1556, XP002974999
CELLA M. ET AL.: "Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon", NAT. MED., vol. 5, no. 8, 1999, pages 919 - 923, XP002243857
LUSTER A.D. ET AL.: "gamma-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins", NATURE, vol. 315, no. 2, 1985, pages 672 - 676, XP002004832
Attorney, Agent or Firm:
Mizuno, Akinobu (22-12 Maruyama-ch, Shibuya-ku Tokyo, JP)
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