Title:
EMX2 IN CANCER DIAGNOSIS AND PROGNOSIS
Document Type and Number:
WIPO Patent Application WO/2010/091296
Kind Code:
A3
Abstract:
The present invention provides methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. The methods generally involve determining a normalized expression level of an EMX2 gene product, which correlates with prognosis and likelihood of survival.
Inventors:
HE BIAO (US)
JABLONS DAVID M (US)
JABLONS DAVID M (US)
Application Number:
PCT/US2010/023378
Publication Date:
April 07, 2011
Filing Date:
February 05, 2010
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
HE BIAO (US)
JABLONS DAVID M (US)
HE BIAO (US)
JABLONS DAVID M (US)
International Classes:
C12Q1/68; C12N15/12; G01N33/574
Foreign References:
| EP1895302A2 | 2008-03-05 |
Other References:
NOONAN ET AL.: "Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers", GENOMICS, vol. 76, no. 1-3, August 2001 (2001-08-01), pages 37 - 44
LIND ET AL.: "Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)", J PATHOL, vol. 210, no. 4, December 2006 (2006-12-01), pages 441 - 449
GANGEMI ET AL.: "Effects of Emx2 inactivation on the gene expression profile of neural precursors", EUR J NEUROSCI, vol. 23, no. 2, January 2006 (2006-01-01), pages 325 - 334
GANGEMI ET AL.: "Emx2 in adult neural precursor cells", MECH DEV, vol. 109, no. 2, December 2001 (2001-12-01), pages 323 - 329
LIND ET AL.: "Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)", J PATHOL, vol. 210, no. 4, December 2006 (2006-12-01), pages 441 - 449
GANGEMI ET AL.: "Effects of Emx2 inactivation on the gene expression profile of neural precursors", EUR J NEUROSCI, vol. 23, no. 2, January 2006 (2006-01-01), pages 325 - 334
GANGEMI ET AL.: "Emx2 in adult neural precursor cells", MECH DEV, vol. 109, no. 2, December 2001 (2001-12-01), pages 323 - 329
Attorney, Agent or Firm:
PARENT, Annette S. et al. (Two Embarcadero Center Eighth Floo, San Francisco California, US)
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