Title:
ENCAPSULATED CELL FOR THERAPY
Document Type and Number:
WIPO Patent Application WO2004058305
Kind Code:
A3
Abstract:
Cell therapy comprises encapsulating a cell with an integrin or other cell interaction factor, for administration to a mammal. The cells may express a therapeutic transgene or the cells may be regenerative.
Inventors:
STEWART DUNCAN J (CA)
COURTMAN DAVID (CA)
KAROUBI GOLNAZ (CA)
COURTMAN DAVID (CA)
KAROUBI GOLNAZ (CA)
Application Number:
PCT/CA2003/002008
Publication Date:
March 31, 2005
Filing Date:
December 24, 2003
Export Citation:
Assignee:
AN GO GEN INC (CA)
STEWART DUNCAN J (CA)
COURTMAN DAVID (CA)
KAROUBI GOLNAZ (CA)
STEWART DUNCAN J (CA)
COURTMAN DAVID (CA)
KAROUBI GOLNAZ (CA)
International Classes:
A61K9/50; C12N5/077; C12N5/0775; C12N11/04; A61K35/12; (IPC1-7): C12N11/04; A61K35/00
Domestic Patent References:
| WO1998005304A1 | 1998-02-12 | |||
| WO1995019430A1 | 1995-07-20 |
Other References:
RAMDI HAFIDA ET AL: "Influence of matricial molecules on growth and differentiation of entrapped chondrocytes", EXPERIMENTAL CELL RESEARCH, vol. 207, no. 2, 1993, pages 449 - 454, XP002275507, ISSN: 0014-4827
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, JAIN KANTI ET AL: "Retrievable, replaceable, macroencapsulated pancreatic islet xenografts", XP002275511, Database accession no. PREV199598235605
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; MARLER ET AL: "Soft-tissue augmentation with injectable alginate and syngeneic fibroblasts", XP002275512, Database accession no. NLM10839402
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; HALBERSTADT ET AL: "A hydrogel material for plastic and reconstructive applications injected into the subcutaneous space of a sheep", XP002275513, Database accession no. NLM12031119
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 2002 (2002-07-01), PARK KEUN-HONG: "Improved long-term culture of hepatocytes in a hydrogel containing Arg-Gly-Asp (RGD)", XP002275514, Database accession no. PREV200200500968
BURDICK JASON A ET AL: "Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering", BIOMATERIALS, vol. 23, no. 22, November 2002 (2002-11-01), pages 4315 - 4323, XP002275508, ISSN: 0142-9612
NUTTELMAN CHARLES R ET AL: "Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 57, no. 2, November 2001 (2001-11-01), pages 217 - 223, XP002275509, ISSN: 0021-9304
MANN BRENDA K ET AL: "Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering", BIOMATERIALS, vol. 22, no. 22, November 2001 (2001-11-01), pages 3045 - 3051, XP002275510, ISSN: 0142-9612
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 1999 (1999-01-01), ROWLEY JON A ET AL: "Alginate hydrogels as synthetic extracellular matrix materials", XP002275515, Database accession no. PREV199900058021
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KOH ET AL: "Molding of hydrogel microstructures to create multiphenotype cell microarrays", XP002275516, Database accession no. NLM14588018
KAROUBI GOLNAZ ET AL: "Cell micro-encapsulation with integrin binding proteins prevents anoikis: Implications for adherent cell therapy.", CIRCULATION, vol. 108, no. 17 Supplement, 28 October 2003 (2003-10-28), American Heart Association Scientific Sessions 2003;Orlando, FL, USA; November 09-12, 2003, pages IV - 286, XP008029277, ISSN: 0009-7322 (ISSN print)
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, JAIN KANTI ET AL: "Retrievable, replaceable, macroencapsulated pancreatic islet xenografts", XP002275511, Database accession no. PREV199598235605
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; MARLER ET AL: "Soft-tissue augmentation with injectable alginate and syngeneic fibroblasts", XP002275512, Database accession no. NLM10839402
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; HALBERSTADT ET AL: "A hydrogel material for plastic and reconstructive applications injected into the subcutaneous space of a sheep", XP002275513, Database accession no. NLM12031119
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; July 2002 (2002-07-01), PARK KEUN-HONG: "Improved long-term culture of hepatocytes in a hydrogel containing Arg-Gly-Asp (RGD)", XP002275514, Database accession no. PREV200200500968
BURDICK JASON A ET AL: "Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering", BIOMATERIALS, vol. 23, no. 22, November 2002 (2002-11-01), pages 4315 - 4323, XP002275508, ISSN: 0142-9612
NUTTELMAN CHARLES R ET AL: "Attachment of fibronectin to poly(vinyl alcohol) hydrogels promotes NIH3T3 cell adhesion, proliferation, and migration", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, vol. 57, no. 2, November 2001 (2001-11-01), pages 217 - 223, XP002275509, ISSN: 0021-9304
MANN BRENDA K ET AL: "Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering", BIOMATERIALS, vol. 22, no. 22, November 2001 (2001-11-01), pages 3045 - 3051, XP002275510, ISSN: 0142-9612
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 1999 (1999-01-01), ROWLEY JON A ET AL: "Alginate hydrogels as synthetic extracellular matrix materials", XP002275515, Database accession no. PREV199900058021
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KOH ET AL: "Molding of hydrogel microstructures to create multiphenotype cell microarrays", XP002275516, Database accession no. NLM14588018
KAROUBI GOLNAZ ET AL: "Cell micro-encapsulation with integrin binding proteins prevents anoikis: Implications for adherent cell therapy.", CIRCULATION, vol. 108, no. 17 Supplement, 28 October 2003 (2003-10-28), American Heart Association Scientific Sessions 2003;Orlando, FL, USA; November 09-12, 2003, pages IV - 286, XP008029277, ISSN: 0009-7322 (ISSN print)
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