ENCODED MOLECULES BY TRANSLATION (EMT)

Title:

ENCODED MOLECULES BY TRANSLATION (EMT)

Document Type and Number:

WIPO Patent Application WO2004110964

Kind Code:

A3

Abstract:

The present invention is directed to methods for the synthesis, selection, amplification and isolation of templated molecules having desirable properties. The invention makes it possible to synthesise a variety of different templated molecules other than alpha-peptides and modified alpha-peptides. In particular, the present invention enables synthesis of templated molecules such as beta -, ϒ -, ϖ peptides, carbopeptoids, vinylogous peptides, oligoanthrilamides, oligoureas, azapeptides (azatides), oligocarbamates, PNA, oligopyrrolinones, vinylogous sulfonamidopeptide, peptoids, azapeptoids and hydrazino peptides. It is possible in accordance with the methods of the invention to synthesise templated molecules comprising heterocyclic components, such as coumarins and quinolones, pyrazolone, isoxazolone, pyrimidiones, phtalhydrazides, diketopiperazines, hydantoins, and benzodiazepines.

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Inventors:

PEDERSEN HENRIK (DK)
FRANCH THOMAS (DK)

Application Number:

PCT/DK2004/000416

Publication Date:

March 31, 2005

Filing Date:

June 15, 2004

Export Citation:

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Assignee:

NUEVOLUTION AS (DK)
PEDERSEN HENRIK (DK)
FRANCH THOMAS (DK)

International Classes:

C07B61/00; C12N15/10; C12N15/67; (IPC1-7): C12N15/10; C07B61/00; C12N15/67

Domestic Patent References:

WO2002059293A2	2002-08-01
WO2002103008A2	2002-12-27
WO2002074929A2	2002-09-26
WO2000023458A1	2000-04-27
WO2002085923A2	2002-10-31
WO1998031700A1	1998-07-23
WO2001007657A1	2001-02-01

Foreign References:

DE19646372C1	1997-06-19
EP0962527A1	1999-12-08

Other References:

FORSTER ANTHONY C ET AL: "Programming peptidomimetic syntheses by translating genetic codes designed de novo.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 11, 27 May 2003 (2003-05-27), pages 6353 - 6357, XP002316170, ISSN: 0027-8424

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