Title:
ENDOPLASMIC RETICULUM STRESS INHIBITOR, NEURODEGENERATIVE DISEASE PREVENTING/IMPROVING AGENT, AGENT FOR PREVENTION/PROGRESSION PREVENTION/IMPROVEMENT OF DEMENTIA, AND FOOD PRODUCT
Document Type and Number:
WIPO Patent Application WO/2023/068285
Kind Code:
A1
Abstract:
Provided is an endoplasmic reticulum stress inhibitor that contains, as an active ingredient, a triglyceride represented by formula (I) (in the formula, R1, R2, and R3 are each a saturated fatty acid residue, and at least one thereof is a pentadecanoic acid residue). Provided are an endoplasmic reticulum stress inhibitor and a neurodegenerative disease preventing/improving agent, each of which can be taken in the long term and can be used as food, beverage, or a drug for prevention, symptom reduction, and/or improvement.
Inventors:
TSUBOI MAKOTO (JP)
SAKATA YASUKO (JP)
SAKATA YASUKO (JP)
Application Number:
PCT/JP2022/038842
Publication Date:
April 27, 2023
Filing Date:
October 19, 2022
Export Citation:
Assignee:
REFINE HOLDINGS CO LTD (JP)
International Classes:
A61K31/23; A23L33/105; A23L33/115; A61K36/02; A61P25/00; A61P25/28; A61P43/00
Domestic Patent References:
| WO2019052629A1 | 2019-03-21 | |||
| WO2020054804A1 | 2020-03-19 | |||
| WO2021107084A1 | 2021-06-03 | |||
| WO2021020514A1 | 2021-02-04 |
Foreign References:
| JP2019518034A | 2019-06-27 | |||
| JP2020533019A | 2020-11-19 |
Other References:
SASAKI KAZUNORI, GERIBALDI-DOLDÁN NOELIA, WU QINGQING, DAVIES JULIE, SZELE FRANCIS G., ISODA HIROKO: "Microalgae Aurantiochytrium Sp. Increases Neurogenesis and Improves Spatial Learning and Memory in Senescence-Accelerated Mouse-Prone 8 Mice", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 8, XP093057643, DOI: 10.3389/fcell.2020.600575
WANG FANG, LI HAILI, ZHAO HANG, ZHANG YA, QIU PENGCHENG, LI JIE, WANG SIWANG: "Antidiabetic Activity and Chemical Composition of Sanbai Melon Seed Oil", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 2018, 1 January 2018 (2018-01-01), US , pages 1 - 14, XP093057645, ISSN: 1741-427X, DOI: 10.1155/2018/5434156
MARYCZ KRZYSZTOF, MICHALAK IZABELA, KOCHEROVA IEVGENIIA, MARĘDZIAK MONIKA, WEISS CHRISTINE: "The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV’s)", MARINE DRUGS, vol. 15, no. 12, pages 385, XP093057647, DOI: 10.3390/md15120385
BOUREBABA LYNDA; MICHALAK IZABELA; ROCKEN MICHAEL; MARYCZ KRZYSZTOF: "Cladophora glomeratamethanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs)", BIOMEDICINE & PHARMACOTHERAPY, vol. 111, 1 January 1900 (1900-01-01), FR , pages 6 - 18, XP085604403, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2018.12.020
TSUBOI, MAKOTO: "New Health Function Nutrients Included in Edible Microalgae: Hitherto Unknown Physical Health-Promoting Nutrients Made Clear", FOOD STYLE, vol. 26, no. 5, May 2022 (2022-05-01), pages 33 - 36, XP009545388
TSUBOI, MAKOTO: "New Anti-Aging Science Food Ingredients that Alleviate Endoplasmic Reticulum Stress", FOOD PROCESSING AND INGREDIENTS, vol. 57, no. 7, July 2022 (2022-07-01), pages 88 - 89, XP009545375
TSUBOI, MAKOTO ET AL.: "Alleviating endoplasmic reticulum stress in human skin cells caused by photoaging", FRAGRANCE JOURNAL, vol. 50, no. 7, 15 July 2022 (2022-07-15), pages 43 - 53
TSUBOI, MAKOTO.: "A new endoplasmic reticulum stress-relieving component produced by the microalga Aurantiochytrium limacinum", FRAGRANCE JOURNAL, vol. 50, no. 9, 15 September 2022 (2022-09-15), pages 37 - 42, XP009545367
WANG FANG, LI HAILI, ZHAO HANG, ZHANG YA, QIU PENGCHENG, LI JIE, WANG SIWANG: "Antidiabetic Activity and Chemical Composition of Sanbai Melon Seed Oil", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol. 2018, 1 January 2018 (2018-01-01), US , pages 1 - 14, XP093057645, ISSN: 1741-427X, DOI: 10.1155/2018/5434156
MARYCZ KRZYSZTOF, MICHALAK IZABELA, KOCHEROVA IEVGENIIA, MARĘDZIAK MONIKA, WEISS CHRISTINE: "The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV’s)", MARINE DRUGS, vol. 15, no. 12, pages 385, XP093057647, DOI: 10.3390/md15120385
BOUREBABA LYNDA; MICHALAK IZABELA; ROCKEN MICHAEL; MARYCZ KRZYSZTOF: "Cladophora glomeratamethanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs)", BIOMEDICINE & PHARMACOTHERAPY, vol. 111, 1 January 1900 (1900-01-01), FR , pages 6 - 18, XP085604403, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2018.12.020
TSUBOI, MAKOTO: "New Health Function Nutrients Included in Edible Microalgae: Hitherto Unknown Physical Health-Promoting Nutrients Made Clear", FOOD STYLE, vol. 26, no. 5, May 2022 (2022-05-01), pages 33 - 36, XP009545388
TSUBOI, MAKOTO: "New Anti-Aging Science Food Ingredients that Alleviate Endoplasmic Reticulum Stress", FOOD PROCESSING AND INGREDIENTS, vol. 57, no. 7, July 2022 (2022-07-01), pages 88 - 89, XP009545375
TSUBOI, MAKOTO ET AL.: "Alleviating endoplasmic reticulum stress in human skin cells caused by photoaging", FRAGRANCE JOURNAL, vol. 50, no. 7, 15 July 2022 (2022-07-15), pages 43 - 53
TSUBOI, MAKOTO.: "A new endoplasmic reticulum stress-relieving component produced by the microalga Aurantiochytrium limacinum", FRAGRANCE JOURNAL, vol. 50, no. 9, 15 September 2022 (2022-09-15), pages 37 - 42, XP009545367
Attorney, Agent or Firm:
NAKAJIMA Yuki (JP)
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