Title:
ENGINEERED IMMUNE CELL AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/037461
Kind Code:
A1
Abstract:
Provided are an engineered immune cell and a preparation method therefor. The engineered immune cell is prepared by means of transfecting an isolated nucleic acid molecule. The isolated nucleic acid molecule comprises: a nucleic acid sequence encoding a chimeric antigen receptor (CAR); a nucleic acid sequence encoding IL-15 or a functional active fragment thereof; and a nucleic acid sequence encoding IL-21 or a functional active fragment thereof.
Inventors:
LI LINHONG (CN)
ZHU XIANGYANG (CN)
YU SHIJUN (CN)
XIN PENGCHENG (CN)
WANG LI (CN)
YANG XINGXING (CN)
ZHAN YIFAN (CN)
ZHU XIANGYANG (CN)
YU SHIJUN (CN)
XIN PENGCHENG (CN)
WANG LI (CN)
YANG XINGXING (CN)
ZHAN YIFAN (CN)
Application Number:
PCT/CN2023/112683
Publication Date:
February 22, 2024
Filing Date:
August 11, 2023
Export Citation:
Assignee:
CELLS & GENES BIOTECH SHANGHAI CO LTD (CN)
International Classes:
C12N15/62; A61P35/00; C12N5/10
Domestic Patent References:
| WO2019210293A1 | 2019-10-31 | |||
| WO2021202793A2 | 2021-10-07 |
Foreign References:
| CN104894068A | 2015-09-09 | |||
| CN110616187A | 2019-12-27 |
Other References:
BATRA SAI ARUN, RATHI PURVA, GUO LINJIE, COURTNEY AMY N., FLEURENCE JULIEN, BALZEAU JULIEN, SHAIK RAHAMTHULLA S., NGUYEN THAO P., : "Glypican-3–Specific CAR T Cells Coexpressing IL15 and IL21 Have Superior Expansion and Antitumor Activity against Hepatocellular Carcinoma", CANCER IMMUNOLOGY RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 8, no. 3, 1 March 2020 (2020-03-01), US , pages 309 - 320, XP055828198, ISSN: 2326-6066, DOI: 10.1158/2326-6066.CIR-19-0293
GOV CLINICALTRIALS, HECZEY ANDRAS: "Interleukin-15 and -21 Armored Glypican-3-speci c Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors", CLINICALTRIALS NCT04715191, 1 December 2021 (2021-12-01), XP093140368, Retrieved from the Internet [retrieved on 20240312]
JUSTIN EYQUEM, JORGE MANSILLA-SOTO, THEODOROS GIAVRIDIS, SJOUKJE J. C. VAN DER STEGEN, MOHAMAD HAMIEH, KRISTEN M. CUNANAN, ASHLESH: "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection", NATURE, vol. 543, no. 7643, pages 113 - 117, XP055397283, DOI: 10.1038/nature21405
GOV CLINICALTRIALS, HECZEY ANDRAS: "Interleukin-15 and -21 Armored Glypican-3-speci c Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors", CLINICALTRIALS NCT04715191, 1 December 2021 (2021-12-01), XP093140368, Retrieved from the Internet
JUSTIN EYQUEM, JORGE MANSILLA-SOTO, THEODOROS GIAVRIDIS, SJOUKJE J. C. VAN DER STEGEN, MOHAMAD HAMIEH, KRISTEN M. CUNANAN, ASHLESH: "Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection", NATURE, vol. 543, no. 7643, pages 113 - 117, XP055397283, DOI: 10.1038/nature21405
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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