Title:
ENGINEERED IMMUNE CELL AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/016284
Kind Code:
A1
Abstract:
The present invention relates to an engineered immune cell which expresses (i) a cell surface molecule specifically recognizing an antigen, and (ii) an exogenous CCL2. The present invention further provides a use of the engineered immune cell in the treatment of cancers, infections or autoimmune diseases. Compared with traditional engineered immune cells, the engineered immune cell of the present invention has significantly improved tumor-killing activity.
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Inventors:
XING YUN (CN)
REN JIANGTAO (CN)
REN JIANGTAO (CN)
Application Number:
PCT/CN2022/109101
Publication Date:
February 16, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
NANJING BIOHENG BIOTECH CO LTD (CN)
International Classes:
C12N5/10; A61K39/00; A61P31/00; A61P33/00; A61P35/00; C12N15/12; C12N15/24; C12N15/62; C12N15/867
Foreign References:
| CN110272873A | 2019-09-24 | |||
| CN112063588A | 2020-12-11 | |||
| CN101443357A | 2009-05-27 | |||
| CN110117329A | 2019-08-13 | |||
| CN109153989A | 2019-01-04 | |||
| CN111849910A | 2020-10-30 |
Other References:
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens mRNA for IL7 nirs variant 2, complete cds", XP093034206, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "interleukin-7 isoform 2 precursor [Homo sapiens]", XP093034208, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Mus musculus interleukin 7, mRNA (cDNA clone MGC:129342 IMAGE:40047584), complete", XP093034212, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "Interleukin 7 [Mus musculus]", XP093034214, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Mus musculus chemokine (C-C motif) ligand 2, mRNA (cDNA clone MGC:175754 IMAGE:40131170), complete cds", XP093034218, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens cDNA, FLJ92229, Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA", XP093034221, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "interleukin-7 isoform 2 precursor [Homo sapiens]", XP093034208, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Mus musculus interleukin 7, mRNA (cDNA clone MGC:129342 IMAGE:40047584), complete", XP093034212, retrieved from NCBI
DATABASE PROTEIN ANONYMOUS : "Interleukin 7 [Mus musculus]", XP093034214, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Mus musculus chemokine (C-C motif) ligand 2, mRNA (cDNA clone MGC:175754 IMAGE:40131170), complete cds", XP093034218, retrieved from NCBI
DATABASE NUCLEOTIDE ANONYMOUS : "Homo sapiens cDNA, FLJ92229, Homo sapiens chemokine (C-C motif) ligand 2 (CCL2), mRNA", XP093034221, retrieved from NCBI
Attorney, Agent or Firm:
FOUNDIN INTELLECTUAL PROPERTY (CN)
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