Title:
ENGINEERED MICROORGANISM FOR TREATING HYPERPHENYLALANINEMIA AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/165521
Kind Code:
A1
Abstract:
An engineered microorganism, which comprises one or more of a gene encoding an aromatic amino acid transaminase, a gene encoding phenylalanine dehydrogenase, a gene encoding phenylpyruvate decarboxylase, a gene encoding an aldehyde reductase, a gene encoding glutamate dehydrogenase, and a gene encoding a phenylalanine transport protein, or a functional equivalent thereof. The present invention also relates to a composition comprising the engineered microorganism; a method for using the engineered microorganism or the composition to alleviate and/or treat diseases and/or conditions associated with hyperphenylalaninemia; and use of the engineered microorganism or the composition in the preparation of medicaments or health products for treating diseases and/or conditions associated with hyperphenylalaninemia.
Inventors:
XIANG BIN (CN)
SUN WANJU (CN)
LIU CUICUI (CN)
ZHU LI (CN)
SUN WANJU (CN)
LIU CUICUI (CN)
ZHU LI (CN)
Application Number:
PCT/CN2023/079034
Publication Date:
September 07, 2023
Filing Date:
March 01, 2023
Export Citation:
Assignee:
COMMBIO THERAPEUTICS CO LTD (CN)
International Classes:
C12N1/21; A61K35/74; A61K35/741; A61K48/00; A61P3/00; C12N15/70; C12R1/19
Domestic Patent References:
| WO2016183531A1 | 2016-11-17 |
Foreign References:
| CN112662606A | 2021-04-16 | |||
| CN106566794A | 2017-04-19 | |||
| CN112662607A | 2021-04-16 | |||
| CN113969292A | 2022-01-25 |
Attorney, Agent or Firm:
BEIJING HAN KUN LAW OFFICES (CN)
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