ENGRAFTMENT PROMOTER FOR RETINAL PIGMENT EPITHELIAL CELL TRANSPLANTATION

WIPO Patent Application WO/2022/009969

A1

The present invention provides a method for promoting the engraftment of RPE cells transplanted for treating a retinal degenerative disease such as macular degeneration or retinitis pigmentosa (RP) and a method for preventing rejection of the transplanted allogeneic RPE cells by recipient's lymphocytes.

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WO/2002/024920	ISOLATED HUMAN KINASE PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN KINASE PROTEINS, AND USES THEREOF
JP2004529108	A pharmaceutical formulation containing R-salmeterol and fluticasone propionate.

TAKAHASHI MASAYO (JP)
SUGITA SUNAO (JP)

PCT/JP2021/025888

January 13, 2022

July 09, 2021

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RIKEN (JP)

A61K45/00; A61K31/4409; A61K35/30; A61P27/02; A61P37/06; A61P43/00; C12N5/0789; C12N5/079; C12N5/10; C12N9/99

WO2016067629A1

2016-05-06

JP2014533289A	2014-12-11
JP2016106591A	2016-06-20
JP2018188410A	2018-11-29

NI, Y. ET AL.: "ROCK Inhibitor Y-27632 Promotes Human Retinal Pigment Epithelium Survival by Altering Cellular Biomechanical Properties", CURRENT MOLECULAR MEDICINE, vol. 17, no. 9, 2017, pages 637 - 646, XP055835677, DOI: 10.2174/156652401866618031615093
KINOSHITA, S. ET AL.: "Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy", THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 378, 2018, pages 995 - 1003, XP055898487, DOI: 10.1056/NEJMoa1712770
ISHIDA, M. ET AL.: "A ROCK Inhibitor Promotes Craft Survival during Transplantation of iPS- Cell - Derived Retinal Cells", INT. J. MOL. SCI., vol. 22, no. 6, 22 March 2021 (2021-03-22), pages 1 - 18, XP055898489, DOI: 10.3390/ijms22063237

TAKASHIMA, Hajime (JP)

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