Title:
ENVIRONMENT-FRIENDLY PREPARATION METHOD FOR N-METHYLAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/240791
Kind Code:
A1
Abstract:
Disclosed in the present invention is an environment-friendly preparation method for an N-methylamide compound. An LED lamp is used as a light source to provide energy, an economical and easily available tertiary amide is used as a reaction substrate, copper chloride is used as a catalyst, hydrochloric acid available in the market is used as an additive, and acetone is used as a solvent. Compared with the prior art, the method provided by the present invention has the following advantages that a green, mild and environment-friendly visible light catalysis reaction mode is adopted; the reaction system is simple, the range of substrate is wide, and aromatic and aliphatic amides are both suitable for the method; the reaction yield is relatively high; and the operation is relatively simple, and the raw materials are cheap and easy to obtain.
Inventors:
WAN XIAOBING (CN)
LIAN PENGCHENG (CN)
LI RUYI (CN)
WAN XIAO (CN)
XIANG ZIXIN (CN)
LI MINGXIANG (CN)
LIAN PENGCHENG (CN)
LI RUYI (CN)
WAN XIAO (CN)
XIANG ZIXIN (CN)
LI MINGXIANG (CN)
Application Number:
PCT/CN2022/113978
Publication Date:
December 21, 2023
Filing Date:
August 22, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C231/08; C07C233/07; C07C233/11; C07C233/58; C07C233/59; C07C233/65; C07C235/20; C07C235/46; C07C235/60; C07C255/57; C07D333/38; C07D333/70
Foreign References:
| CN1990474A | 2007-07-04 | |||
| CN113717071A | 2021-11-30 | |||
| CN110698360A | 2020-01-17 | |||
| CN112321449A | 2021-02-05 | |||
| CN110818584A | 2020-02-21 | |||
| JPS60149551A | 1985-08-07 | |||
| CN111253275A | 2020-06-09 |
Other References:
YI XUEWEN, LEI SIYU, LIU WANGSHENG, CHE FENGRUI, YU CHUNZHENG, LIU XUESONG, WANG ZONGHUA, ZHOU XIN, ZHANG YUEXIA: "Copper-Catalyzed Radical N-Demethylation of Amides Using N -Fluorobenzenesulfonimide as an Oxidant", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 22, no. 12, 19 June 2020 (2020-06-19), US , pages 4583 - 4587, XP093117563, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.0c00863
CYBULARCZYK-CECOTKA MARTYNA, PREDYGIER JĘDRZEJ, CRESPI STEFANO, SZCZEPANIK JOANNA, GIEDYK MACIEJ: "Photocatalysis in Aqueous Micellar Media Enables Divergent C–H Arylation and N -Dealkylation of Benzamides", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 6, 18 March 2022 (2022-03-18), US , pages 3543 - 3549, XP093117564, ISSN: 2155-5435, DOI: 10.1021/acscatal.2c00468
TANAKA FRED S., WIEN RONALD G., MANSAGER EUGENE R.: "Photolytic demethylation of monuron and demethylmonuron in aqueous solution", PESTICIDE SCIENCE., ELSEVIER APPLIED SCIENCE PUBLISHER. BARKING., GB, vol. 13, no. 3, 1 June 1982 (1982-06-01), GB , pages 287 - 294, XP093117567, ISSN: 0031-613X, DOI: 10.1002/ps.2780130310
CYBULARCZYK-CECOTKA MARTYNA, PREDYGIER JĘDRZEJ, CRESPI STEFANO, SZCZEPANIK JOANNA, GIEDYK MACIEJ: "Photocatalysis in Aqueous Micellar Media Enables Divergent C–H Arylation and N -Dealkylation of Benzamides", ACS CATALYSIS, AMERICAN CHEMICAL SOCIETY, US, vol. 12, no. 6, 18 March 2022 (2022-03-18), US , pages 3543 - 3549, XP093117564, ISSN: 2155-5435, DOI: 10.1021/acscatal.2c00468
TANAKA FRED S., WIEN RONALD G., MANSAGER EUGENE R.: "Photolytic demethylation of monuron and demethylmonuron in aqueous solution", PESTICIDE SCIENCE., ELSEVIER APPLIED SCIENCE PUBLISHER. BARKING., GB, vol. 13, no. 3, 1 June 1982 (1982-06-01), GB , pages 287 - 294, XP093117567, ISSN: 0031-613X, DOI: 10.1002/ps.2780130310
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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