Title:
ENZYME INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2022/118016
Kind Code:
A3
Abstract:
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in medicine; and methods of treating patients with such compounds; wherein A, W, R5, n, Z, X, Y and B are as defined herein. The present invention also relates to compounds useful as synthetic intermediates of compounds of formula (I).
Inventors:
CHILDS MITCHELL LEWIS (GB)
DAVIE REBECCA LOUISE (GB)
EDWARDS HANNAH JOY (GB)
EVANS DAVID MICHAEL (GB)
GREVES WILLIAM JACK (GB)
HODGSON SIMON TEANBY (GB)
MAZZACANI ALESSANDRO (GB)
NORTH CARL LESLIE (GB)
OBARA ALICJA STELA (GB)
ROE MICHAEL BRYAN (GB)
ROOKER DAVID PHILIP (GB)
STOCKS MICHAEL JOHN (GB)
BIRCH LOUISE MICHELLE (GB)
PICHOWICZ MARK (GB)
PITTAWAY RACHAEL (GB)
SMITH ALUN JOHN (GB)
THROUP ADAM ERIC (GB)
WRIGGLESWORTH JOSEPH WILLIAM (GB)
YANG XUEZHENG (GB)
CLARK DAVID EDWARD (GB)
DAVIE REBECCA LOUISE (GB)
EDWARDS HANNAH JOY (GB)
EVANS DAVID MICHAEL (GB)
GREVES WILLIAM JACK (GB)
HODGSON SIMON TEANBY (GB)
MAZZACANI ALESSANDRO (GB)
NORTH CARL LESLIE (GB)
OBARA ALICJA STELA (GB)
ROE MICHAEL BRYAN (GB)
ROOKER DAVID PHILIP (GB)
STOCKS MICHAEL JOHN (GB)
BIRCH LOUISE MICHELLE (GB)
PICHOWICZ MARK (GB)
PITTAWAY RACHAEL (GB)
SMITH ALUN JOHN (GB)
THROUP ADAM ERIC (GB)
WRIGGLESWORTH JOSEPH WILLIAM (GB)
YANG XUEZHENG (GB)
CLARK DAVID EDWARD (GB)
Application Number:
PCT/GB2021/053137
Publication Date:
July 07, 2022
Filing Date:
December 01, 2021
Export Citation:
Assignee:
KALVISTA PHARMACEUTICALS LTD (GB)
International Classes:
C07D401/12; C07D401/14; C07D471/04; C07D471/08; C07D487/04; C07D519/00
Domestic Patent References:
| WO2019108565A1 | 2019-06-06 | |||
| WO2008086462A2 | 2008-07-17 | |||
| WO2012068589A2 | 2012-05-24 | |||
| WO2016201052A1 | 2016-12-15 |
Foreign References:
| US20030225106A1 | 2003-12-04 | |||
| EP3388433A1 | 2018-10-17 | |||
| US20200262813A1 | 2020-08-20 |
Other References:
DE CANDIA MODESTO ET AL: "Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 21, 14 November 2013 (2013-11-14), US, pages 8696 - 8711, XP055883434, ISSN: 0022-2623, DOI: 10.1021/jm401169a
LONGHURST HILARY ET AL: "Hereditary angio-oedema", THE LANCET, vol. 379, no. 9814, 1 February 2012 (2012-02-01), AMSTERDAM, NL, pages 474 - 481, XP055884258, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60935-5
ZHU G D ET AL: "Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 12, 15 June 2006 (2006-06-15), pages 3150 - 3155, XP027965568, ISSN: 0960-894X, [retrieved on 20060615]
LONGHURST HILARY ET AL: "Hereditary angio-oedema", THE LANCET, vol. 379, no. 9814, 1 February 2012 (2012-02-01), AMSTERDAM, NL, pages 474 - 481, XP055884258, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(11)60935-5
ZHU G D ET AL: "Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 16, no. 12, 15 June 2006 (2006-06-15), pages 3150 - 3155, XP027965568, ISSN: 0960-894X, [retrieved on 20060615]
Attorney, Agent or Firm:
MCGUIRE, Gillian Margaret et al. (GB)
Download PDF:
Previous Patent: INSTALLING EQUIPMENT IN OFFSHORE MONOPILE FOUNDATIONS
Next Patent: ROBOTIC MEAL PREPARATION SYSTEM
Next Patent: ROBOTIC MEAL PREPARATION SYSTEM