Title:
ENZYME INVOLVED IN SYNTHESIS OF EQUOL
Document Type and Number:
WIPO Patent Application WO/2009/084603
Kind Code:
A1
Abstract:
Disclosed are: enzymes involved in the synthesis of equol; genes respectively encoding the enzymes; and a method for producing equol or an intermediate thereof by using the enzymes. Specifically disclosed are: a dihydrodaidzein synthase, a tetrahydrodaidzein synthase, and an equol synthase; genes respectively encoding the synthases; and a method for synthesizing dihydrodaidzein, tetrahydrodaidzein and/or equol by using the enzymes.
Inventors:
SHIMADA YOSHIKAZU (JP)
YASUDA SETSUKO (JP)
TAKAHASHI MASAYUKI (JP)
HAYASHI TAKASHI (JP)
MIYAZAWA NORIHIRO (JP)
ABIRU YASUHIRO (JP)
OHTANI TADAAKI (JP)
SATO IKUTARO (JP)
YASUDA SETSUKO (JP)
TAKAHASHI MASAYUKI (JP)
HAYASHI TAKASHI (JP)
MIYAZAWA NORIHIRO (JP)
ABIRU YASUHIRO (JP)
OHTANI TADAAKI (JP)
SATO IKUTARO (JP)
Application Number:
PCT/JP2008/073649
Publication Date:
July 09, 2009
Filing Date:
December 25, 2008
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
SHIMADA YOSHIKAZU (JP)
YASUDA SETSUKO (JP)
TAKAHASHI MASAYUKI (JP)
HAYASHI TAKASHI (JP)
MIYAZAWA NORIHIRO (JP)
ABIRU YASUHIRO (JP)
OHTANI TADAAKI (JP)
SATO IKUTARO (JP)
SHIMADA YOSHIKAZU (JP)
YASUDA SETSUKO (JP)
TAKAHASHI MASAYUKI (JP)
HAYASHI TAKASHI (JP)
MIYAZAWA NORIHIRO (JP)
ABIRU YASUHIRO (JP)
OHTANI TADAAKI (JP)
SATO IKUTARO (JP)
International Classes:
C12N9/02; C12N15/09; C12P17/18
Domestic Patent References:
| WO2000066576A1 | 2000-11-09 | |||
| WO2007099764A1 | 2007-09-07 |
Foreign References:
| JP2006296434A | 2006-11-02 | |||
| JP2006296434A | 2006-11-02 |
Other References:
See also references of EP 2228441A4
"IUPAC-IUB Communication on Biological Nomenclature", EUR. J. BIOCHEM., vol. 138, 1984, pages 9
PROC. NATL. ACAD. SCI., USA., vol. 78, 1981, pages 6613
SCIENCE, vol. 222, 1983, pages 778
SCIENCE, vol. 130, 1985, pages 1350
RAPID AMPLIFICATION OF CDNA ENDS, EXPERIMENTAL MEDICINE, vol. 12, no. 6, 1994, pages 35
M.A. FROHMAN ET AL., PROC. NATL. ACAD. SCI., USA., vol. 8, 1988, pages 8998
BIOCHEMISTRY, vol. 25, no. 25, 1986, pages 8274
EUR. J. BIOCHEM., vol. 163, 1987, pages 313
KINOSHITA, M. ET AL., CCA, vol. 228, 1994, pages 83 - 90
ORITA, M. ET AL., GENOMICS, vol. 5, 1989, pages 874 - 879
"IUPAC-IUB Communication on Biological Nomenclature", EUR. J. BIOCHEM., vol. 138, 1984, pages 9
PROC. NATL. ACAD. SCI., USA., vol. 78, 1981, pages 6613
SCIENCE, vol. 222, 1983, pages 778
SCIENCE, vol. 130, 1985, pages 1350
RAPID AMPLIFICATION OF CDNA ENDS, EXPERIMENTAL MEDICINE, vol. 12, no. 6, 1994, pages 35
M.A. FROHMAN ET AL., PROC. NATL. ACAD. SCI., USA., vol. 8, 1988, pages 8998
BIOCHEMISTRY, vol. 25, no. 25, 1986, pages 8274
EUR. J. BIOCHEM., vol. 163, 1987, pages 313
KINOSHITA, M. ET AL., CCA, vol. 228, 1994, pages 83 - 90
ORITA, M. ET AL., GENOMICS, vol. 5, 1989, pages 874 - 879
Attorney, Agent or Firm:
Saegusa & Partners et al. (1-7-1 Doshomachi,Chuo-ku,Osaka-sh, Osaka 45, JP)
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