EPHA2-TARGETING ANTIBODIES AND THEIR APPLICATIONS IN CANCER TREATMENT

Title:

EPHA2-TARGETING ANTIBODIES AND THEIR APPLICATIONS IN CANCER TREATMENT

Document Type and Number:

WIPO Patent Application WO/2023/230624

Kind Code:

A3

Abstract:

The present disclosure relates to anti- EphA2 antibody and cancer detection (or diagnosis) and treatment using the anti- EphA2 antibody. The present invention creates anti- EphA2 antibodies, particularly, a single-chain antibody fragments (scFv) and humanized antibody, which have ability in binding to anti- EphA2 and in inhibiting angiogenesis, migration and cancer cell growth.

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Inventors:

YEN YUN (US)
LEE YU-CHING (TW)
CHANG FU-LING (TW)

Application Number:

PCT/US2023/067573

Publication Date:

March 07, 2024

Filing Date:

May 26, 2023

Export Citation:

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Assignee:

UNIV TAIPEI MEDICAL (TW)
YEN YUN (US)

International Classes:

C07K16/28; A61K39/00; A61K39/395; A61P35/00

Domestic Patent References:

WO2017100289A2

2017-06-15

Foreign References:

US20040028685A1	2004-02-12
US20190187132A1	2019-06-20
US20200140554A1	2020-05-07
US20200262915A1	2020-08-20

Attorney, Agent or Firm:

BATHKE, Amy (US)

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