Title:
EPIGENETICS ANALYSIS OF CELL-FREE DNA
Document Type and Number:
WIPO Patent Application WO/2024/022529
Kind Code:
A1
Abstract:
Measuring quantities (e.g., relative frequencies) of particular sequence motifs of cell-free DNA fragments in a biological sample can be used to analyze the biological sample. The particular sequence motifs or sequence sizes in certain genomic regions may indicate a histone modification. The sequence motifs and/or sizes can be used to measure a property of the sample (e.g., fractional concentration of a tissue type or a characteristic of the tissue type), to measure an amount of histone modifications, to determine a condition of the organism based on such measurements, and to enrich a biological sample for clinically-relevant DNA. Different tissue types can exhibit different patterns for the relative frequencies of the sequence motifs. Measures of the relative frequencies of sequence motifs of cell-free DNA can be used for analysis.
More Like This:
Inventors:
LO YUK-MING DENNIS (CN)
JIANG PEIYONG (CN)
CHAN KWAN CHEE (CN)
YUKAWA MASASHI (CN)
JI LU (CN)
BAI JINYUE (CN)
JIANG PEIYONG (CN)
CHAN KWAN CHEE (CN)
YUKAWA MASASHI (CN)
JI LU (CN)
BAI JINYUE (CN)
Application Number:
PCT/CN2023/110154
Publication Date:
February 01, 2024
Filing Date:
July 31, 2023
Export Citation:
Assignee:
CENTRE FOR NOVOSTICS (CN)
International Classes:
C12Q1/6883; C12Q1/6809; C12Q1/6869; G16B20/00
Domestic Patent References:
| WO2018009723A1 | 2018-01-11 |
Foreign References:
| US20200199656A1 | 2020-06-25 | |||
| CN108330181A | 2018-07-27 | |||
| CN105463090A | 2016-04-06 | |||
| CN113366122A | 2021-09-07 | |||
| US20110189677A1 | 2011-08-04 | |||
| US20210024994A1 | 2021-01-28 |
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
Download PDF: