Title:
EPITOPE OF HEPATITIS B VIRUS SURFACE ANTIGEN AND BINDING MOLECULE SPECIFICALLY BINDING TO SAME FOR NEUTRALIZING HEPATITIS B VIRUS
Document Type and Number:
WIPO Patent Application WO/2016/085284
Kind Code:
A1
Abstract:
The present invention relates to an epitope specific to hepatitis B virus surface antigen and a binding molecule binding to the same for neutralizing hepatitis B virus. Since the epitope provided by the present invention is produced by forming a three-dimensional structure and does not comprise a determinant, by which escape mutation is induced against an administration of existing vaccines or HBIg, a composition comprising an antibody biding to the epitope or a vaccine composition comprising the epitope has a very low possibility of causing a decrease in efficacy due to escape mutation. Therefore, such an antibody or vaccine composition can be very effectively used in prevention and/or treatment of HBV.
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Inventors:
YOON JOON SUN (KR)
LEE HWA JIN (KR)
YI KYE SOOK (KR)
KIM CHEOL MIN (KR)
LIM BYUNG PIL (KR)
CHANG SHIN JAE (KR)
HONG SEUNG SUH (KR)
LEE HWA JIN (KR)
YI KYE SOOK (KR)
KIM CHEOL MIN (KR)
LIM BYUNG PIL (KR)
CHANG SHIN JAE (KR)
HONG SEUNG SUH (KR)
Application Number:
PCT/KR2015/012820
Publication Date:
June 02, 2016
Filing Date:
November 27, 2015
Export Citation:
Assignee:
CELLTRION INC (KR)
International Classes:
C07K14/02; A61K39/29; A61K39/395; A61P31/20; C07K16/08; C12N15/13; C12N15/51
Foreign References:
| US20110033838A1 | 2011-02-10 | |||
| KR101281098B1 | 2013-07-02 | |||
| US7067247B2 | 2006-06-27 |
Other References:
ROQUE-AFONSO ET AL.: "Viral and clinical factors associated with surface gene variants among hepatitis B virus carriers", ANTIVIRAL THERAPY, vol. 12, 2007, pages 1255 - 1263, XP003032456
CARMAN ET AL.: "The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa , and Sardinia", HEPATOLOGY, vol. 26, no. 6, 1997, pages 1658 - 1666, XP000914649, DOI: doi:10.1002/hep.510260640
See also references of EP 3225628A4
CARMAN ET AL.: "The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa , and Sardinia", HEPATOLOGY, vol. 26, no. 6, 1997, pages 1658 - 1666, XP000914649, DOI: doi:10.1002/hep.510260640
See also references of EP 3225628A4
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