Title:
EPITOPE AND ITS USE OF HEPATITIS B VIRUS SURFACE ANTIGEN
Document Type and Number:
WIPO Patent Application WO/2013/002449
Kind Code:
A1
Abstract:
Disclosed are an epitope specific to hepatitis B virus (HBV) and use thereof. The disclosed epitope is a conservative position on which mutagenesis does not occur and, therefore, a composition including an antibody to the foregoing epitope or a vaccine composition including the epitope has very low possibility of causing degradation of curing efficacy due to HBV mutation, thus being very useful for HBV treatment.
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Inventors:
KIM SE-HO (KR)
HONG KWANG-WON (KR)
SHIN YONG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
IM JUNG-AE (KR)
HONG KWANG-WON (KR)
SHIN YONG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
IM JUNG-AE (KR)
Application Number:
PCT/KR2011/005477
Publication Date:
January 03, 2013
Filing Date:
July 25, 2011
Export Citation:
Assignee:
GREEN CROSS CORP (KR)
KIM SE-HO (KR)
HONG KWANG-WON (KR)
SHIN YONG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
IM JUNG-AE (KR)
KIM SE-HO (KR)
HONG KWANG-WON (KR)
SHIN YONG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
IM JUNG-AE (KR)
International Classes:
C07K14/02; A61K39/42; A61P31/20; C07K17/02; C12N7/01; C12N15/36; C12N15/63; C12N15/85
Foreign References:
| KR19990008648A | 1999-02-05 |
Other References:
SZOMOR ET AL.: "Mutation spectra of the surface-protein-coding region of the HBV genome in HBV-vaccinated and non-vaccinated individuals in Hungary", ARCHIVES OF VIROLOGY, vol. 153, no. 10, 24 September 2008 (2008-09-24), pages 1885 - 1892, XP019660397
DATABASE NCBI [online] 8 December 1999 (1999-12-08), XP003033712, Database accession no. AAF15849
DATABASE NCBI [online] 8 December 1999 (1999-12-08), XP003033713, Database accession no. AAF15606
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
DEUSCHER, M.: "Guide to Protein Purification Methods Enzymology", vol. 182, 1990, ACADEMIC PRESS, INC.
See also references of EP 2726499A4
DATABASE NCBI [online] 8 December 1999 (1999-12-08), XP003033712, Database accession no. AAF15849
DATABASE NCBI [online] 8 December 1999 (1999-12-08), XP003033713, Database accession no. AAF15606
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
DEUSCHER, M.: "Guide to Protein Purification Methods Enzymology", vol. 182, 1990, ACADEMIC PRESS, INC.
See also references of EP 2726499A4
Attorney, Agent or Firm:
KWON, Oh-Sig et al. (921 Dunsan-dong, Seo-gu, Daejeon 302-120, KR)
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Claims: