Title:
EPITOPES OF EPIDERMAL GROWTH FACTOR RECEPTOR SURFACE ANTIGEN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/147509
Kind Code:
A1
Abstract:
The present invention relates to epitopes of the epidermal growth factor receptor (EGFR) and the use thereof. The epitopes provided by the present invention are highly preserved, and located in the domain closely related to binding with an epidermal growth factor (EGF). Therefore, vaccine compositions comprising the epitopes or compositions comprising antibodies to the epitopes may efficiently block a signal transduction caused by binding of EGF and EGRF, and thus can be highly valuably used in treating various diseases such as cancer. An antibody bound to the epitopes of the present invention may efficiently inhibit binding of various EGFR ligands such as not only EGF but also TGF-a, AR, BTC, EPR and HB-EGF, with EGFR, and therefore can be used in treating various diseases resulting from an activation of EGFR caused by binding not only with EGF but also with other EGFR ligands.
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Inventors:
KIM SE-HO (KR)
HONG KWANG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
LEE MI-JUNG (KR)
WON JONG-HWA (KR)
HUR MIN-KYU (KR)
CHO HYUN-SOO (KR)
YOO JI-HO (KR)
HONG KWANG-WON (KR)
CHANG KI HWAN (KR)
KIM MIN-SOO (KR)
LEE MI-JUNG (KR)
WON JONG-HWA (KR)
HUR MIN-KYU (KR)
CHO HYUN-SOO (KR)
YOO JI-HO (KR)
Application Number:
PCT/KR2013/002550
Publication Date:
October 03, 2013
Filing Date:
March 27, 2013
Export Citation:
Assignee:
GREEN CROSS CORP (KR)
MOGAM BIOTECH RES INST (KR)
MOGAM BIOTECH RES INST (KR)
International Classes:
A61K38/17; A61K38/16; A61K39/395; A61K48/00; A61P35/00
Domestic Patent References:
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Other References:
GARRETT TP ET AL., CELL, vol. 110, 2002, pages 763 - 773
STAMOS J ET AL., J BIOL. CHERH., vol. 277, 2002, pages 46265 - 46272
S. YOKOYAMA ET AL., CELL, vol. 110, 2002, pages 775 - 787
SAMBROOK ET AL.: "Molecular Cloning: A laborarory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
DEUSCHER, M.: "Guide to Protein Purification Methods Enzymology", vol. 182, 1990, ACADEMIC PRESS. INC.
FERGUSON ET AL., MOLECULAR CELL, vol. 11, 2003, pages 507 - 517
BODER, E.T. ET AL., NAT BIOTECHNOL., vol. 15, no. 6, 1997, pages 553 - 7
See also references of EP 2832363A4
STAMOS J ET AL., J BIOL. CHERH., vol. 277, 2002, pages 46265 - 46272
S. YOKOYAMA ET AL., CELL, vol. 110, 2002, pages 775 - 787
SAMBROOK ET AL.: "Molecular Cloning: A laborarory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
DEUSCHER, M.: "Guide to Protein Purification Methods Enzymology", vol. 182, 1990, ACADEMIC PRESS. INC.
FERGUSON ET AL., MOLECULAR CELL, vol. 11, 2003, pages 507 - 517
BODER, E.T. ET AL., NAT BIOTECHNOL., vol. 15, no. 6, 1997, pages 553 - 7
See also references of EP 2832363A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
이처영 (KR)
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