Title:
EPOTHILONE DERIVATIVES AND METHODS FOR MAKING AND USING THE SAME
Document Type and Number:
WIPO Patent Application WO2002080846
Kind Code:
A3
Abstract:
This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful in the treatment of diseases or conditions characterized by cellular hyperproliferation. This invention also relates to means for the preparation of compounds of Formula (I); formulations containing compounds of formula (I); and methods for the use of said compounds and formulations in the treatment of a disease or condition characterized by cellular hyperproliferation, including cancer.
Inventors:
ASHLEY GARY
ARSLANIAN ROBERT L
CARNEY JOHN
METCALF BRIAN
TANG LI
ARSLANIAN ROBERT L
CARNEY JOHN
METCALF BRIAN
TANG LI
Application Number:
PCT/US2002/010468
Publication Date:
December 04, 2003
Filing Date:
April 02, 2002
Export Citation:
Assignee:
KOSAN BIOSCIENCES INC (US)
International Classes:
C07D313/00; C07D405/06; C07D413/06; C07D417/06; C07D491/04; C12N1/20; C12N9/00; C12N15/52; C12N15/74; C12P17/16; C12P17/18; (IPC1-7): A61K31/33; C07D225/02; C07D225/04; C07D291/00; C07D491/00; C12P17/00; C12P17/02
Domestic Patent References:
| WO1999007692A2 | 1999-02-18 |
Foreign References:
| US6383787B1 | 2002-05-07 |
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