Title:
ESTABLISHMENT OF ERYTHROID PRECURSOR CELL LINE CAPABLE OF CONDITIONAL MATURATION USING GENE OVEREXPRESSION
Document Type and Number:
WIPO Patent Application WO/2023/096380
Kind Code:
A1
Abstract:
The present invention relates to the establishment of an immortalized erythroid precursor cell line capable of conditional maturation, and more specifically, the present invention provides an erythroid precursor cell for producing an erythrocyte having E6/E7 and Bcl-xL genes transduced therein, and a preparation method therefor.
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Inventors:
BAEK EUN JUNG (KR)
KIM SUYEON (KR)
JO KYEONG WON (KR)
PARK JU MI (KR)
KIM SUYEON (KR)
JO KYEONG WON (KR)
PARK JU MI (KR)
Application Number:
PCT/KR2022/018737
Publication Date:
June 01, 2023
Filing Date:
November 24, 2022
Export Citation:
Assignee:
IUCF HYU (KR)
International Classes:
C12N5/078
Foreign References:
| KR20190142257A | 2019-12-26 | |||
| JP2016165265A | 2016-09-15 | |||
| KR20080073282A | 2008-08-08 | |||
| KR20140011912A | 2014-01-29 |
Other References:
WONG SUSAN, KEYVANFAR KEYVAN, WAN ZHIHONG, KAJIGAYA SACHIKO, YOUNG NEAL S., ZHI NING: "Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC., US, vol. 38, no. 11, 1 November 2010 (2010-11-01), US , pages 994 - 1005.e2, XP055804546, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2010.07.012
SHO-ICHI HIROSE, NAOYA TAKAYAMA, SOU NAKAMURA, KAZUMICHI NAGASAWA, KIYOSUMI OCHI, SHINJI HIRATA, SATOSHI YAMAZAKI, TOMOYUKI YAMAGU: "Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 1, no. 6, 1 December 2013 (2013-12-01), United States , pages 499 - 508, XP055435471, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2013.10.010
A. CAULIER, L. GUYONNEAU HARMAND, L. GARÇON: "Immortalisation érythrocytaire pour production de globules rouges in vitro", TRANSFUSION CLINIQUE ET BIOLOGIQUE., ARNETTE-BLACKWELL, PARIS., FR, vol. 24, no. 3, 1 September 2017 (2017-09-01), FR , pages 263 - 267, XP055435562, ISSN: 1246-7820, DOI: 10.1016/j.tracli.2017.06.030
"Master's thesis", 28 February 2022, HANYANG UNIVERSITY, Korea, article JO, KYEONG WON: "Generation of immoratlized erythroid progenitor cells using HPV16 E6/E7", pages: 1 - 43, XP009546588
SHO-ICHI HIROSE, NAOYA TAKAYAMA, SOU NAKAMURA, KAZUMICHI NAGASAWA, KIYOSUMI OCHI, SHINJI HIRATA, SATOSHI YAMAZAKI, TOMOYUKI YAMAGU: "Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 1, no. 6, 1 December 2013 (2013-12-01), United States , pages 499 - 508, XP055435471, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2013.10.010
A. CAULIER, L. GUYONNEAU HARMAND, L. GARÇON: "Immortalisation érythrocytaire pour production de globules rouges in vitro", TRANSFUSION CLINIQUE ET BIOLOGIQUE., ARNETTE-BLACKWELL, PARIS., FR, vol. 24, no. 3, 1 September 2017 (2017-09-01), FR , pages 263 - 267, XP055435562, ISSN: 1246-7820, DOI: 10.1016/j.tracli.2017.06.030
"Master's thesis", 28 February 2022, HANYANG UNIVERSITY, Korea, article JO, KYEONG WON: "Generation of immoratlized erythroid progenitor cells using HPV16 E6/E7", pages: 1 - 43, XP009546588
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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