Title:
ESTROGEN RECEPTOR GENES AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/052010
Kind Code:
A1
Abstract:
Estrogen receptor genes characterized by having a base sequence encoding any of the following amino acid sequences, etc.: (a) the amino acid sequence represented by SEQ ID NO:1; (b) an amino acid sequence having a sequence identity of 85% or higher to the amino acid sequence represented by SEQ ID NO:1 and being an amino acid sequence of a protein having an estrogen receptor activity; (c) an amino acid sequence encoded by the base sequence represented by SEQ ID NO:2; and (d) an amino acid sequence encoded by a base sequence having a sequence identity of 85% or higher to a DNA having the base sequence represented by SEQ ID NO:2 and being an amino acid sequence of a protein having an estrogen receptor activity; are provided. These genes are usable in, for example, a test system for evaluating the ability of a chemical to control the estrogen receptor activity.
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Inventors:
SUMIDA KAYO (JP)
Application Number:
PCT/JP2001/009995
Publication Date:
July 04, 2002
Filing Date:
November 15, 2001
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
SUMIDA KAYO (JP)
SUMIDA KAYO (JP)
International Classes:
C07K14/46; C07K14/72; C12N15/12; G01N33/74; (IPC1-7): C12N15/12; C07K14/72; C12N5/10; C12P21/02; C12Q1/02; G01N33/566; G01N33/50; G01N33/53
Domestic Patent References:
| WO1999011760A1 | 1999-03-11 |
Foreign References:
| JP2000201688A | 2000-07-25 |
Other References:
ANDREE KRUST ET AL.: "The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors", THE EMBO JOURNAL, vol. 5, no. 5, 1986, pages 891 - 897, XP001057526
ERIN C. JACOBS ET AL.: "Zebra fish estrogen receptor cDNA: Cloning and mRNA expression", J. STEROID BIOCHEM. MOLEC. BIOL., vol. 59, no. 2, 1996, pages 135 - 145, XP002907921
DIRK BOEKENKAMP ET AL.: "The C-terminal half of the porcine estradiol receptor contains no post-translational modification: determination of the primary structure", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 104, 1994, pages 163 - 172, XP002907922
MARC VIDAL ET AL.: "Survey and summary: Yeast forward and reverse 'n'-hybrid systems", NUCLEIC ACIDS RESEARCH, vol. 27, no. 4, 1999, pages 919 - 929, XP002907923
ERIN C. JACOBS ET AL.: "Zebra fish estrogen receptor cDNA: Cloning and mRNA expression", J. STEROID BIOCHEM. MOLEC. BIOL., vol. 59, no. 2, 1996, pages 135 - 145, XP002907921
DIRK BOEKENKAMP ET AL.: "The C-terminal half of the porcine estradiol receptor contains no post-translational modification: determination of the primary structure", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 104, 1994, pages 163 - 172, XP002907922
MARC VIDAL ET AL.: "Survey and summary: Yeast forward and reverse 'n'-hybrid systems", NUCLEIC ACIDS RESEARCH, vol. 27, no. 4, 1999, pages 919 - 929, XP002907923
Attorney, Agent or Firm:
Kuboyama, Takashi c/o SUMITOMO CHEMICAL INTELLECTUAL PROPERTY SERVICE (LIMITED 5-33 Kitahama 4-chom, Chuo-ku Osaka-shi Osaka, JP)
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