Title:
ETHYLIDENE HYDRAZINE CARBOXAMIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2009/103218
Kind Code:
A1
Abstract:
Ethylidene hydrazidecarboxamide derivatives of formula (I) or pharmaceutically acceptable salts, hydrate or solvation thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in formula (I) are the same as the description.
Inventors:
TANG PENG CHO (CN)
LU HEJUN (CN)
CHEN YIQIAN (CN)
SONG PENG (CN)
WANG SHENGLAN (CN)
LU HEJUN (CN)
CHEN YIQIAN (CN)
SONG PENG (CN)
WANG SHENGLAN (CN)
Application Number:
PCT/CN2009/000136
Publication Date:
August 27, 2009
Filing Date:
February 06, 2009
Export Citation:
Assignee:
SHANGHAI HENGRUI PHARM CO LTD (CN)
TANG PENG CHO (CN)
LU HEJUN (CN)
CHEN YIQIAN (CN)
SONG PENG (CN)
WANG SHENGLAN (CN)
TANG PENG CHO (CN)
LU HEJUN (CN)
CHEN YIQIAN (CN)
SONG PENG (CN)
WANG SHENGLAN (CN)
International Classes:
C07D207/263; A61K31/4015; A61K31/4152; A61K31/4155; A61P7/04; A61P43/00; C07C243/38; C07D209/14; C07D231/22; C07D257/04; C07D403/12
Domestic Patent References:
| WO2007062078A2 | 2007-05-31 | |||
| WO2006064957A1 | 2006-06-22 | |||
| WO2006028970A1 | 2006-03-16 | |||
| WO2003032916A2 | 2003-04-24 |
Foreign References:
| US20060069140A1 | 2006-03-30 |
Other References:
ZHONG MENG ET AL.: "Synthesis and antibactiral of derivatives ofN4-substituted thiosemicarbazone", HECHENG HUAXUE(CHINESE), vol. 5, no. 3, 1997, pages 305 - 308
CHAI HUI ET AL.: "Crystal structure of a novel compound. 1-Phenyl-3-methyl-4-[2-(salicyl hydrazido)propylidene]-5-pyrazolone", JIEGOU HUAXUE, vol. 24, no. 9, 2005, pages 1091 - 1095
ZHANG LI ET AL.: "Synthesis and structure of complex Ni(DPBP-SAH)2 ? 2CH3CH2OH", WUJI HUAXUE XUEBAO, vol. 21, no. 2, 2005, pages 291 - 294
CHAI HUI ET AL.: "Crystal structure of a novel compound. 1-Phenyl-3-methyl-4-[2-(salicyl hydrazido)propylidene]-5-pyrazolone", JIEGOU HUAXUE, vol. 24, no. 9, 2005, pages 1091 - 1095
ZHANG LI ET AL.: "Synthesis and structure of complex Ni(DPBP-SAH)2 ? 2CH3CH2OH", WUJI HUAXUE XUEBAO, vol. 21, no. 2, 2005, pages 291 - 294
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, CN)
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