Title:
EUTECTIC CRYSTAL OF TEMOZOLOMIDE AND BAICALEIN AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/205909
Kind Code:
A1
Abstract:
An eutectic crystal of temozolomide and baicalein and a preparation method therefor. Specifically, the X-ray powder diffraction pattern of the eutectic crystal has characteristic peaks at 2theta values of 7.7 ± 0.2°, 8.6 ± 0.2°, and 12.7 ± 0.2°. Compared with the existing temozolomide and baicalein active pharmaceutical ingredients, the two drug components in the eutectic crystal have obvious advantages in terms of stability, solubility, pharmacokinetic properties and the like, being of great value for the future development of the combination of the two drugs.
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Inventors:
CHEN JIAMEI (CN)
LU TONGBU (CN)
LI JINMEI (CN)
LU TONGBU (CN)
LI JINMEI (CN)
Application Number:
PCT/CN2019/081368
Publication Date:
October 31, 2019
Filing Date:
April 04, 2019
Export Citation:
Assignee:
UNIV TIANJIN TECHNOLOGY (CN)
International Classes:
C07D487/04; A61K31/352; A61K31/4188; A61P35/00; A61P35/02; C07D311/30
Foreign References:
| CN108623601A | 2018-10-09 |
Other References:
LI, JINMEI ET AL.: "Constructing Anti-Glioma Drug Combination with Optimized Properties through Cocrystallization", CRYST. GROWTH DES., vol. 18, 17 July 2018 (2018-07-17), pages 4270 - 4274, XP055650132, ISSN: 1528-7483
ZHANG, LAN ET AL.: "UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target", J. MED. CHEM., vol. 61, 6 March 2018 (2018-03-06), pages 6491 - 6500, XP055650134, ISSN: 0022-2623
WANG, FURONG ET AL.: "Effect of treatment with baicalein on the intracerebral tumor growth and survival of orthotopic glioma models", J NEUROONCOL, vol. 124, 13 May 2015 (2015-05-13), pages 5 - 11, XP035510798, ISSN: 0167-594X, DOI: 10.1007/s11060-015-1804-3
ZHANG, LAN ET AL.: "UNC-51-like Kinase 1: From an Autophagic Initiator to Multifunctional Drug Target", J. MED. CHEM., vol. 61, 6 March 2018 (2018-03-06), pages 6491 - 6500, XP055650134, ISSN: 0022-2623
WANG, FURONG ET AL.: "Effect of treatment with baicalein on the intracerebral tumor growth and survival of orthotopic glioma models", J NEUROONCOL, vol. 124, 13 May 2015 (2015-05-13), pages 5 - 11, XP035510798, ISSN: 0167-594X, DOI: 10.1007/s11060-015-1804-3
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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