Title:
EXATECAN DERIVATIVE-ANTIBODY CONJUGATE AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/138635
Kind Code:
A1
Abstract:
Disclosed in the present invention are an antibody-drug conjugate of a novel Exatecan analogue, a pharmaceutical composition containing the conjugate, and a medical use of the conjugate and the pharmaceutical composition. The novel Exatecan analogue of the present invention has very strong tumour inhibition efficiency, and the provided TROP-2 antibody-drug conjugate and HER3 antibody-drug conjugate have good tumour inhibition effects and good prospects for clinical application.
Inventors:
QIN WENFANG (CN)
YIN LEI (CN)
JIAO JIAO (CN)
GU MENGJUN (CN)
CHEN YIKUN (CN)
QIAO JING (CN)
YIN LEI (CN)
JIAO JIAO (CN)
GU MENGJUN (CN)
CHEN YIKUN (CN)
QIAO JING (CN)
Application Number:
PCT/CN2023/073014
Publication Date:
July 27, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
GAN & LEE PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K47/68; A61K31/4745; A61K31/48; A61P35/00; C07K16/28; C07K16/30
Domestic Patent References:
| WO2022068878A1 | 2022-04-07 | |||
| WO2022011075A1 | 2022-01-13 |
Foreign References:
| CN112533958A | 2021-03-19 | |||
| CN109081871A | 2018-12-25 | |||
| CN113939318A | 2022-01-14 | |||
| EP2910573A1 | 2015-08-26 | |||
| EP3130608A1 | 2017-02-15 |
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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