Title:
EXHAUSTIVE SEARCHING FOR CRYSTALS
Document Type and Number:
WIPO Patent Application WO/2011/115069
Kind Code:
A1
Abstract:
Disclosed is a method for preparing the various salts of a target compound, the co-crystal of the salts, the solvate of the salts and the co-crystal, and/or the crystal form of the salts, the co-crystal and the solvate, which involves: a step (1) for preparing an amorphous of a free form or the salt thereof, or a low-crystallinity solid of the free form, the salt thereof, the co-crystal of the free form and the salt, or the solvate of the free form, the salt and the co-crystal; a step (2) for exposing said amorphous or said low-crystallinity solid to a solvent vapor; a step (3) for analyzing the crystal form of the compound obtained in step (2); and a step (4) for repeating steps (1) to (3) for no less than one time by varying the solvent vapor exposure conditions.
More Like This:
Inventors:
KOBAYASHI KATSUHIRO
YAMAWAKI HIROYUKI
YAMAWAKI HIROYUKI
Application Number:
PCT/JP2011/055958
Publication Date:
September 22, 2011
Filing Date:
March 14, 2011
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
KOBAYASHI KATSUHIRO
YAMAWAKI HIROYUKI
KOBAYASHI KATSUHIRO
YAMAWAKI HIROYUKI
International Classes:
C07D209/28; C07D211/90; C07D213/76; C07D417/12; C07J9/00
Domestic Patent References:
| WO2008073757A1 | 2008-06-19 |
Foreign References:
| JPH06199667A | 1994-07-19 | |||
| JP2009538904A | 2009-11-12 | |||
| JP2010505771A | 2010-02-25 | |||
| JP2001527067A | 2001-12-25 | |||
| JP2003531173A | 2003-10-21 | |||
| JP2008503495A | 2008-02-07 |
Other References:
NORIAKI HIRAYAMA, HANDBOOK - GENRI TO KNOW-HOW, 2008, pages 57 - 65, 78 TO 79
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
Download PDF:
Claims: