Title:
EXOPOLYSACCHARIDE SEPARATED FROM LACTOBACILLUS DELBRUECKII AND STREPTOCOCCUS THERMOPHILUS FERMENTED YOGHOURT AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/066163
Kind Code:
A1
Abstract:
The present invention relates to the field of food processing. Disclosed are an exopolysaccharide separated from Lactobacillus delbrueckii and Streptococcus thermophilus fermented yoghourt and an application thereof. The neutral exopolysaccharide of the present invention is extracted from Lactobacillus delbrueckii DMLD-H1 and Streptococcus thermophilus DMST-H2 fermented yoghourt for the first time, and has uniform components, a novel structure, a weight-average molecular weight of 32063 Da, and a monosaccharide composition molar ratio of galactose: glucose of 42.04: 57.96. A scanning electron microscope is adopted to find that the polysaccharide shows a sheet-shaped structure, and a Congo red experiment result shows that the neutral polysaccharide may have a three-dimensional spiral structure. Animal experiments prove that the neutral exopolysaccharide is good in colitis treatment effect and has a wide application prospect in the fields of food and medicines.
Inventors:
LIU DONGMEI (CN)
TANG JUN (CN)
XU YIQIAN (CN)
WU JIAJUAN (CN)
XIONG JIE (CN)
YU JIAJIA (CN)
XIAO LANFANG (CN)
LIN JIN (CN)
TANG JUN (CN)
XU YIQIAN (CN)
WU JIAJUAN (CN)
XIONG JIE (CN)
YU JIAJIA (CN)
XIAO LANFANG (CN)
LIN JIN (CN)
Application Number:
PCT/CN2022/125459
Publication Date:
April 27, 2023
Filing Date:
October 14, 2022
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
C08B37/00; A23L33/125; A61K31/715; A61P1/00; C12N1/20; C12P19/04; C12P39/00; C12R1/225; C12R1/46
Domestic Patent References:
| WO2010023178A1 | 2010-03-04 |
Foreign References:
| CN113861303A | 2021-12-31 | |||
| US20200296979A1 | 2020-09-24 | |||
| CN110607255A | 2019-12-24 | |||
| CN110607253A | 2019-12-24 | |||
| JP3017493B1 | 2000-03-06 | |||
| US6696057B1 | 2004-02-24 | |||
| US20070298019A1 | 2007-12-27 | |||
| CN111631262A | 2020-09-08 | |||
| CN103571775A | 2014-02-12 | |||
| CN105104533A | 2015-12-02 |
Other References:
李莎 马成杰 徐志平 徐爱才 华宝珍 李莎 马成杰 徐志平 徐爱才 华宝珍, ，徐志平，徐爱才，华宝珍, SHA LI, CHENGJIE MA, ZHIPING XU, AICAI XU, BAOZHEN HUA, 中图分类号：TS252: "不同发酵特性的嗜热链球菌与保加利亚乳杆菌共发酵的特性", FOOD SCIENCE, BEIJING FOOD SCIENCE RESEARCH INSTITUTE, CN, vol. 36, no. 15, 1 January 2015 (2015-01-01), CN , pages 123 - 127, XP093057718, ISSN: 1002-6630, DOI: 10.7506/spkx1002-6630-201515023
王兴华等 (WANG, XINGHUA ET AL.): "嗜热链球菌胞外多糖纯化条件的研究 (Research on Purification Condition of Exopolysaccharide of Streptococcus Thermophilus)", 安徽农业科学 (JOURNAL OF ANHUI AGRICULTURAL SCIENCES), vol. 38, no. 32, 10 November 2010 (2010-11-10), ISSN: 0517-6611
WASILEWSKA E.; ZLOTKOWSKA D.; WROBLEWSKA B.: "Yogurt starter cultures ofStreptococcus thermophilusandLactobacillus bulgaricusameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION, US, vol. 102, no. 1, 19 October 2018 (2018-10-19), US , pages 37 - 53, XP085563694, ISSN: 0022-0302, DOI: 10.3168/jds.2018-14520
王兴华等 (WANG, XINGHUA ET AL.): "嗜热链球菌胞外多糖纯化条件的研究 (Research on Purification Condition of Exopolysaccharide of Streptococcus Thermophilus)", 安徽农业科学 (JOURNAL OF ANHUI AGRICULTURAL SCIENCES), vol. 38, no. 32, 10 November 2010 (2010-11-10), ISSN: 0517-6611
WASILEWSKA E.; ZLOTKOWSKA D.; WROBLEWSKA B.: "Yogurt starter cultures ofStreptococcus thermophilusandLactobacillus bulgaricusameliorate symptoms and modulate the immune response in a mouse model of dextran sulfate sodium-induced colitis", JOURNAL OF DAIRY SCIENCE, AMERICAN DAIRY SCIENCE ASSOCIATION, US, vol. 102, no. 1, 19 October 2018 (2018-10-19), US , pages 37 - 53, XP085563694, ISSN: 0022-0302, DOI: 10.3168/jds.2018-14520
Attorney, Agent or Firm:
HUAXUE IP AGENCY CO., LTD. (CN)
Download PDF:
Previous Patent: USE OF BORNEOL IN PREPARATION OF DRUG FOR TREATMENT OF CEREBRAL ISCHEMIC STROKE
Next Patent: EVENT OPENING METHOD AND DEVICE
Next Patent: EVENT OPENING METHOD AND DEVICE