Title:
EXOSOME COMPLEX AND MANUFACTURING METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/238837
Kind Code:
A1
Abstract:
Provided are an exosome complex capable of achieving higher therapeutic effects than conventional products, and a manufacturing method thereof. This exosome complex contains an exosome and affinity molecules for a target cell, said affinity molecules including a hydrophobic moiety anchoring to the membrane surface of the exosome and an affinity moiety for the target cell, wherein 5 or more on average of the affinity molecules are contained per exosome.
Inventors:
HORI MIYUKI (JP)
NAKAGAWA FUMIKO (JP)
SHINODA TATSUYA (JP)
HAYASE YOJI (JP)
NAKAGAWA FUMIKO (JP)
SHINODA TATSUYA (JP)
HAYASE YOJI (JP)
Application Number:
PCT/JP2023/020906
Publication Date:
December 14, 2023
Filing Date:
June 06, 2023
Export Citation:
Assignee:
JSR CORP (JP)
International Classes:
C12N5/07; C12N5/0775; C12N15/115; C12N15/88
Domestic Patent References:
| WO2017073535A1 | 2017-05-04 |
Foreign References:
| KR20210112875A | 2021-09-15 | |||
| CN114457038A | 2022-05-10 |
Other References:
ZOU JIANMEI, SHI MULING, LIU XIAOJING, JIN CHENG, XING XIAOJING, QIU LIPING, TAN WEIHONG: "Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 91, no. 3, 5 February 2019 (2019-02-05), US , pages 2425 - 2430, XP055818153, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b05204
ZHANG YADAN, HE JUNLIN, SHEN LIAO, WANG TAO, YANG JUN, LI YAO, WANG YONGAN, QUAN DONGQIN: "Brain-targeted delivery of obidoxime, using aptamer-modified liposomes, for detoxification of organophosphorus compounds", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 329, 1 January 2021 (2021-01-01), AMSTERDAM, NL , pages 1117 - 1128, XP093113134, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.10.039
ARA, M.N.et al, An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells, Biomaterials, 2014, vol. 35, pp. 7110-7120
ZHANG YADAN, HE JUNLIN, SHEN LIAO, WANG TAO, YANG JUN, LI YAO, WANG YONGAN, QUAN DONGQIN: "Brain-targeted delivery of obidoxime, using aptamer-modified liposomes, for detoxification of organophosphorus compounds", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 329, 1 January 2021 (2021-01-01), AMSTERDAM, NL , pages 1117 - 1128, XP093113134, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2020.10.039
ARA, M.N.et al, An aptamer ligand based liposomal nanocarrier system that targets tumor endothelial cells, Biomaterials, 2014, vol. 35, pp. 7110-7120
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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