Title:
EXOSOME CONTAINING CARTILAGE HOMEOSTASIS FACTORS, AND COMPOSITION FOR PREVENTING OR TREATING OSTEOARTHRITIS INCLUDING SAME
Document Type and Number:
WIPO Patent Application WO/2023/075557
Kind Code:
A1
Abstract:
The present invention relates to an exosome containing cartilage homeostasis factors and a composition, including the exosome, for preventing or treating osteoarthritis. The exosome containing cartilage homeostasis factors enables the effective regeneration of cartilage cells and can thus be effectively utilized for preventing or treating osteoarthritis.
Inventors:
KIM JAE YOUNG (KR)
CHWAE YONG JOON (KR)
CHWAE YONG JOON (KR)
Application Number:
PCT/KR2022/016853
Publication Date:
May 04, 2023
Filing Date:
October 31, 2022
Export Citation:
Assignee:
CK EXOGENE CO LTD (KR)
International Classes:
A61K35/545; A61K38/18; A61P19/02
Domestic Patent References:
| WO2018208670A1 | 2018-11-15 |
Foreign References:
| KR20160096553A | 2016-08-16 | |||
| KR20180092348A | 2018-08-20 | |||
| KR20190011213A | 2019-02-01 |
Other References:
WOO, C. H.: "Cell-free therapeutic systems using exosomes derived from human adipose stem cells for the treatment of osteoarthritis", THESIS FOR THE DOCTOR OF PHILOSOPHY, GRADUATE SCHOOL OF HANYANG UNIVERSITY, 2019, pages 1 - 79, XP009546401
LU CHIA-HSIN, YEH TSUNG-SZU, YEH CHIA-LIN, FANG YU-HUA DEAN, SUNG LI-YU, LIN SHIH-YEH, YEN TZU-CHEN, CHANG YU-HAN, HU YU-CHEN: "Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 22, no. 1, 1 January 2014 (2014-01-01), US , pages 186 - 195, XP055951605, ISSN: 1525-0016, DOI: 10.1038/mt.2013.165
THIELEN NATHALIE, VAN DER KRAAN PETER, VAN CAAM ARJAN: "TGFβ/BMP Signaling Pathway in Cartilage Homeostasis", CELLS, vol. 8, no. 9, pages 969, XP093061555, DOI: 10.3390/cells8090969
YOO KWANG, THAPA NIKITA, CHWAE YONG, YOON SEUNG, KIM BEOM, LEE JUNG, JANG YOU, KIM JAEYOUNG: "Transforming growth factor‑β family and stem cell‑derived exosome therapeutic treatment in osteoarthritis (Review)", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 49, no. 5, GR , XP093061558, ISSN: 1107-3756, DOI: 10.3892/ijmm.2022.5118
LU CHIA-HSIN, YEH TSUNG-SZU, YEH CHIA-LIN, FANG YU-HUA DEAN, SUNG LI-YU, LIN SHIH-YEH, YEN TZU-CHEN, CHANG YU-HAN, HU YU-CHEN: "Regenerating Cartilages by Engineered ASCs: Prolonged TGF-β3/BMP-6 Expression Improved Articular Cartilage Formation and Restored Zonal Structure", MOLECULAR THERAPY, ELSEVIER INC., US, vol. 22, no. 1, 1 January 2014 (2014-01-01), US , pages 186 - 195, XP055951605, ISSN: 1525-0016, DOI: 10.1038/mt.2013.165
THIELEN NATHALIE, VAN DER KRAAN PETER, VAN CAAM ARJAN: "TGFβ/BMP Signaling Pathway in Cartilage Homeostasis", CELLS, vol. 8, no. 9, pages 969, XP093061555, DOI: 10.3390/cells8090969
YOO KWANG, THAPA NIKITA, CHWAE YONG, YOON SEUNG, KIM BEOM, LEE JUNG, JANG YOU, KIM JAEYOUNG: "Transforming growth factor‑β family and stem cell‑derived exosome therapeutic treatment in osteoarthritis (Review)", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 49, no. 5, GR , XP093061558, ISSN: 1107-3756, DOI: 10.3892/ijmm.2022.5118
Attorney, Agent or Firm:
SHIM, Kyoung-Shik et al. (KR)
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