Title:
EXPANSION AND CULTURE OF HUMAN-DERIVED NATURAL KILLER CELLS BY USING IGFBP2
Document Type and Number:
WIPO Patent Application WO/2019/231139
Kind Code:
A1
Abstract:
The present invention relates to a method for the expansion and culture of natural killer cells. By using a method for the expansion and culture of natural killer cells, according to the present invention, the proliferation of human-derived natural killer cells is remarkably enhanced such that natural killer cells to be used for cancer treatment can be efficiently obtained.
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Inventors:
LEE KYUNG-MI (KR)
SHIN MIN HWA (KR)
SHIN MIN HWA (KR)
Application Number:
PCT/KR2019/005726
Publication Date:
December 05, 2019
Filing Date:
May 13, 2019
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C12N5/0783
Foreign References:
| KR20110132618A | 2011-12-08 | |||
| KR20170124467A | 2017-11-10 | |||
| KR20170124467A | 2017-11-10 | |||
| KR20170124467A | 2017-11-10 |
Other References:
ANG SONNY, SILVA MARIA, DAWSON MARGARET, FIGLIOLA MATTHEW, MAITI SOURINDRA, HULS HELEN, SHPALL ELIZABETH J, CHAMPLIN RICHARD, LEE : "NK cell proliferation and cytolytic function are compromised in the hypoxic tumor microenvironment", BLOOD, vol. 118, no. 21, 19 November 2010 (2010-11-19), pages 4291, XP009524693, DOI: 10.1182/blood.V116.21.4291.4291
AZAR, W. J .ET AL: "IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells", ENDOCRINOLOGY, 1 September 2011 (2011-09-01), XP055659819, ISSN: 0013-7227, DOI: :10.1210/en.2011-1121
HOEFLICH, A. ET AL: "Physiology and pathophysiology of IGFBP-1 and IGFBP-2- Consensus and dissent on metabolic control and malignant potential", BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 29, no. 5, 8 July 2015 (2015-07-08), pages 685 - 700, XP029290245, ISSN: 1521-690X, DOI: 10.1016/j.beem.2015.07.002
FOULSTONE, E. J.ET AL: "Insulin-like growth factor binding protein 2 (IGFBP-2 ) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor", ENDOCRINOLOGY, vol. 154, no. 5, 2013, pages 1780 - 1793, XP002734164, ISSN: 0013-7227, DOI: 10.1210/en.2012-1970
See also references of EP 3822341A4
AZAR, W. J .ET AL: "IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells", ENDOCRINOLOGY, 1 September 2011 (2011-09-01), XP055659819, ISSN: 0013-7227, DOI: :10.1210/en.2011-1121
HOEFLICH, A. ET AL: "Physiology and pathophysiology of IGFBP-1 and IGFBP-2- Consensus and dissent on metabolic control and malignant potential", BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 29, no. 5, 8 July 2015 (2015-07-08), pages 685 - 700, XP029290245, ISSN: 1521-690X, DOI: 10.1016/j.beem.2015.07.002
FOULSTONE, E. J.ET AL: "Insulin-like growth factor binding protein 2 (IGFBP-2 ) promotes growth and survival of breast epithelial cells: novel regulation of the estrogen receptor", ENDOCRINOLOGY, vol. 154, no. 5, 2013, pages 1780 - 1793, XP002734164, ISSN: 0013-7227, DOI: 10.1210/en.2012-1970
See also references of EP 3822341A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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