Title:
EXPRESSION CASSETTE OF INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN AND AAV-BASED GENE DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/2023/165477
Kind Code:
A1
Abstract:
The present invention relates to a nucleic acid molecule encoding an interleukin 1 receptor antagonist protein, a transgenic expression cassette comprising the nucleic acid molecule, a gene delivery system comprising the transgenic expression cassette and use thereof. The transgenic expression cassette and the gene delivery system of the present invention can be used to treat various diseases that can be improved by blocking the IL-1 signaling pathway, including malignant tumors and inflammatory diseases, such as arthritis, particularly osteoarthritis.
Inventors:
XIAO XIAO (CN)
ZHOU KAIYI (CN)
ZHENG JING (CN)
ZHENG HAO (CN)
JIANG WEI (CN)
DU ZENGMIN (CN)
ZHAO YANG (CN)
CHEN CHEN (CN)
WANG HUI (CN)
WANG TIANYI (CN)
ZHOU KAIYI (CN)
ZHENG JING (CN)
ZHENG HAO (CN)
JIANG WEI (CN)
DU ZENGMIN (CN)
ZHAO YANG (CN)
CHEN CHEN (CN)
WANG HUI (CN)
WANG TIANYI (CN)
Application Number:
PCT/CN2023/078792
Publication Date:
September 07, 2023
Filing Date:
February 28, 2023
Export Citation:
Assignee:
SHANGHAI MYGT BIOPHARMACEUTICAL LLC (CN)
International Classes:
C12N15/12; A61K38/17; A61K48/00; A61P19/02; A61P19/04; A61P29/00; A61P35/00; C07K14/015; C12N15/864
Foreign References:
| CN114457086A | 2022-05-10 | |||
| CN108697813A | 2018-10-23 | |||
| CN113564187A | 2021-10-29 | |||
| CN113584043A | 2021-11-02 |
Other References:
DATABASE Nucleotide 4 February 1997 (1997-02-04), ANONYMOUS: "Human Interleukin 1 Receptor Antagonist (IL1RN) Gene, Complete cds", XP093087549, Database accession no. M63099.1
Attorney, Agent or Firm:
WATSON & BAND INTELLECTUAL PROPERTY AGENT LTD. (CN)
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