Title:
EXPRESSION VECTORS FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS
Document Type and Number:
WIPO Patent Application WO/2014/100073
Kind Code:
A3
Abstract:
The invention provides expression vectors that support high levels of polypeptide expression in mammalian cells. The vectors contain at least one expression cassette for a target polypeptide; an expression cassette for a eukaryotic selectable marker protein; an expression cassette for a bacterial selectable marker protein, and a bacterial plasmid origin of replication.
Inventors:
YE JIANXIN (US)
Application Number:
PCT/US2013/075922
Publication Date:
August 21, 2014
Filing Date:
December 18, 2013
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
YE JIANXIN (US)
YE JIANXIN (US)
International Classes:
C12N15/09; C12N5/10; C12N15/63; C12N15/79; C12N15/85
Foreign References:
| US20110182898A1 | 2011-07-28 | |||
| US20110136689A1 | 2011-06-09 |
Other References:
DATABASE GENBANK [online] 14 November 2006 (2006-11-14), "Human cytomegalovirus strain AD169 complete genome.", XP055264876, accession no. NCBI Database accession no. X17403
Attorney, Agent or Firm:
MERCK SHARP & DOHME CORP. (Rahway, New Jersey, US)
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