Title:
EXTENDING THE LIFETIME OF ANTICOAGULANT OLIGODEOXYNUCLEOTIDE APTAMERS IN BLOOD
Document Type and Number:
WIPO Patent Application WO2000078364
Kind Code:
A3
Abstract:
The present invention is a complex of a polynucleotide having a property of specifically binding to a target protein together with a protein that stabilizes the polynucleotide from degradation and from clearance from the circulation in vivo. Methods for diagnostic imaging and therapeutic uses of the complex are disclosed.
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Inventors:
DOUGAN ALFRED H
WEITZ JEFFREY I
WEITZ JEFFREY I
Application Number:
PCT/CA2000/000751
Publication Date:
August 09, 2001
Filing Date:
June 22, 2000
Export Citation:
Assignee:
UNIV ALBERTA (CA)
International Classes:
A61K47/48; A61K51/00; C12Q1/68; A61P7/02; (IPC1-7): A61K51/08; A61K47/48
Domestic Patent References:
| WO1996040159A1 | 1996-12-19 |
Foreign References:
| US5688670A | 1997-11-18 |
Other References:
DOUGAN, H. ET AL: "Extending the lifetime of anticoagulant oligodeoxynucleotide aptamers in blood", NUCL. MED. BIOL. (2000), 27(3), 289-297, April 2000 (2000-04-01), XP004205326
BOCK L C ET AL: "SELECTION OF SINGLE-STRANDED DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 355, no. 6360, 6 February 1992 (1992-02-06), pages 564 - 566, XP000453533, ISSN: 0028-0836
BOADO, RUBEN J. ET AL: "Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin -biotin system", BIOCONJUGATE CHEM. (1992), 3(6), 519-23, XP002161274
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; DOUGAN, H. (1) ET AL: "Radiohalogenated DNA aptamers.", XP002161282, retrieved from STN
DOUGAN, HAYES ET AL: "Synthesis and radio-iodination of a stannyl oligodeoxyribonucleotide", NUCLEIC ACIDS RES. (1997), 25(14), 2897-2901, XP000982488
BOCK L C ET AL: "SELECTION OF SINGLE-STRANDED DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 355, no. 6360, 6 February 1992 (1992-02-06), pages 564 - 566, XP000453533, ISSN: 0028-0836
BOADO, RUBEN J. ET AL: "Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin -biotin system", BIOCONJUGATE CHEM. (1992), 3(6), 519-23, XP002161274
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; DOUGAN, H. (1) ET AL: "Radiohalogenated DNA aptamers.", XP002161282, retrieved from STN
DOUGAN, HAYES ET AL: "Synthesis and radio-iodination of a stannyl oligodeoxyribonucleotide", NUCLEIC ACIDS RES. (1997), 25(14), 2897-2901, XP000982488
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