Title:
EXTERNAL PREPARATION FOR TREATING EPILEPSY OR AUTISM SPECTRUM DISORDER
Document Type and Number:
WIPO Patent Application WO/2021/075328
Kind Code:
A1
Abstract:
[Problem] To provide a pharmaceutical agent for treating epilepsy, a pharmaceutical agent for treating an autism spectrum disorder, and/or a pharmaceutical agent for treating an anxiety disorder which have high safety and are easily administered. [Solution] An external preparation containing, as an active ingredient, at least one selected from the group consisting of sirolimus and a sirolimus derivative is easily administered, and has a high level of safety as a therapeutic agent for epilepsy, an autism spectrum disorder, and/or an anxiety disorder. A suitable active ingredient may include, for example, sirolimus, everolimus, temsirolimus, ridaforolimus, and zotarolimus.
Inventors:
KANEDA MARI (JP)
Application Number:
PCT/JP2020/037986
Publication Date:
April 22, 2021
Filing Date:
October 07, 2020
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K31/436; A61P25/00; A61P25/08; A61K9/06
Domestic Patent References:
| WO2012105521A1 | 2012-08-09 | |||
| WO2016152519A1 | 2016-09-29 |
Foreign References:
| JP2011526889A | 2011-10-20 | |||
| JP2018535244A | 2018-11-29 | |||
| JP2013528631A | 2013-07-11 |
Other References:
FRENCH JACQUELINE A, LAWSON JOHN A, YAPICI ZUHAL, IKEDA HIROKO, POLSTER TILMAN, NABBOUT RIMA, CURATOLO PAOLO, DE VRIES PETRUS J, D: "Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study", LANCET, vol. 388, 2016, pages 2153 - 2163, XP055818813
KRUEGER, D. A. ET AL.: "Everolimus Treatment of Refractory Epilepsy in Tuberous Sclerosis Comple x", ANN NEUROL., vol. 74, 2013, pages 679 - 687, XP055489979, DOI: 10.1002/ana.23960
CARDAMONE, M. ET AL.: "Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex", J. PEDIATR., vol. 164, 2014, pages 1195 - 1200, XP055489978, DOI: 10.1016/j.jpeds.2013.12.053
SATO, A. ET AL.: "Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex", NATURE COMMUNICATIONS, vol. 3, 2012, pages 1292, XP055320205, DOI: 10.1038/ncomms2295
ISHII RYOUHEI, WATAYA-KANEDA MARI, CANUET LEONIDES, NONOMURA NORIO, NAKAI YASUTOMO, TAKEDA MASATOSHI: "Everolimus improves behavioral deficits in a patient with autism associated with tuberous sclerosis: a case report", NEUROPSYCHIATRIC ELECTROPHYSIOLOGY, vol. 1, no. 6, 2015, pages 1 - 7, XP055818816
BALAK DEEPAK M.W., ZONNENBERG BERNARD A., SPITZER-NAAIJKENS JULIETTE M.J. , HULSHOF MIEKE M.: "A 28-Year-Old Male Patient with Nail Tumors, Skin Lesions, and Epilepsy", CASE REP. DERMATOL., vol. 9, 2017, pages 12 - 19, XP055818818
FRENCH JA ET AL., LANCET, vol. 388, no. 10056, 29 October 2016 (2016-10-29), pages 2153 - 2163
KRUEGER DA ET AL., ANN NEUROL, vol. 74, 2013, pages 679 - 87
CARDAMONE M ET AL., J PEDIATR, vol. 164, 2014, pages 1195 - 200
SATO A ET AL., NATURE COMMUNICATIONS, vol. 3, 2012, pages 1292
ISHII R ET AL., NEUROPSYCHIATRIC ELECTROPHYSIOLOGY, vol. 1, 2015, pages 6
J INVEST DERMATOL, vol. 138, no. 3, 2018, pages 669 - 78
PLOS ONE, vol. 15, no. 1, 2020
See also references of EP 4046637A4
KRUEGER, D. A. ET AL.: "Everolimus Treatment of Refractory Epilepsy in Tuberous Sclerosis Comple x", ANN NEUROL., vol. 74, 2013, pages 679 - 687, XP055489979, DOI: 10.1002/ana.23960
CARDAMONE, M. ET AL.: "Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex", J. PEDIATR., vol. 164, 2014, pages 1195 - 1200, XP055489978, DOI: 10.1016/j.jpeds.2013.12.053
SATO, A. ET AL.: "Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex", NATURE COMMUNICATIONS, vol. 3, 2012, pages 1292, XP055320205, DOI: 10.1038/ncomms2295
ISHII RYOUHEI, WATAYA-KANEDA MARI, CANUET LEONIDES, NONOMURA NORIO, NAKAI YASUTOMO, TAKEDA MASATOSHI: "Everolimus improves behavioral deficits in a patient with autism associated with tuberous sclerosis: a case report", NEUROPSYCHIATRIC ELECTROPHYSIOLOGY, vol. 1, no. 6, 2015, pages 1 - 7, XP055818816
BALAK DEEPAK M.W., ZONNENBERG BERNARD A., SPITZER-NAAIJKENS JULIETTE M.J. , HULSHOF MIEKE M.: "A 28-Year-Old Male Patient with Nail Tumors, Skin Lesions, and Epilepsy", CASE REP. DERMATOL., vol. 9, 2017, pages 12 - 19, XP055818818
FRENCH JA ET AL., LANCET, vol. 388, no. 10056, 29 October 2016 (2016-10-29), pages 2153 - 2163
KRUEGER DA ET AL., ANN NEUROL, vol. 74, 2013, pages 679 - 87
CARDAMONE M ET AL., J PEDIATR, vol. 164, 2014, pages 1195 - 200
SATO A ET AL., NATURE COMMUNICATIONS, vol. 3, 2012, pages 1292
ISHII R ET AL., NEUROPSYCHIATRIC ELECTROPHYSIOLOGY, vol. 1, 2015, pages 6
J INVEST DERMATOL, vol. 138, no. 3, 2018, pages 669 - 78
PLOS ONE, vol. 15, no. 1, 2020
See also references of EP 4046637A4
Attorney, Agent or Firm:
SHOJI Takashi et al. (JP)
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